Proglumid
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- CAS-Nr.
- 6620-60-6
- Bezeichnung:
- Proglumid
- Englisch Name:
- Proglumide
- Synonyma:
- ProM;kxm;xyde;242dl;cr242;milid;nulsa;w5219;milide;Promid
- CBNumber:
- CB2479493
- Summenformel:
- C18H26N2O4
- Molgewicht:
- 334.41
- MOL-Datei:
- 6620-60-6.mol
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Proglumid Eigenschaften
- Schmelzpunkt:
- 148-150°C
- Siedepunkt:
- 471.21°C (rough estimate)
- Dichte
- 1.1944 (rough estimate)
- Brechungsindex
- 1.5700 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 4.51±0.10(Predicted)
- Farbe
- Crystals
- InChI
- InChI=1S/C18H26N2O4/c1-3-12-20(13-4-2)18(24)15(10-11-16(21)22)19-17(23)14-8-6-5-7-9-14/h5-9,15H,3-4,10-13H2,1-2H3,(H,19,23)(H,21,22)
- InChIKey
- DGMKFQYCZXERLX-UHFFFAOYSA-N
- SMILES
- C(O)(=O)CCC(NC(=O)C1=CC=CC=C1)C(N(CCC)CCC)=O
- CAS Datenbank
- 6620-60-6(CAS DataBase Reference)
- EPA chemische Informationen
- Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo- (6620-60-6)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Toxizit?t |
LD50 in mice (mg/kg): 2211-2649 i.v.; 7350-8861 orally (Rovati) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Proglumid Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Proglumide (Milid) is a drug that inhibits gastrointestinal motility and reduces gastric secretions. It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. It was used mainly in the treatment of stomach ulcers, although it has now been largely replaced by newer drugs for this application.
Proglumide is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide selective blocks CCK’s effects in the central nervous system (CNS). Proglumide has ability to inhibit gastric secretion and to protect the gastroduodenal mucosa. Proglumide also has antiepileptic and antioxidant activities.
Chemische Eigenschaften
White Solid
Verwenden
Anticholinergic.
Nebenwirkungen
An interesting side effect of proglumide is that it enhances the analgesia produced by opioid drugs, and can prevent or even reverse the development of tolerance to opioid drugs. This can make it a useful adjuvant treatment to use alongside opioid drugs in the treatment of chronic pain conditions such as cancer, where opioid analgesics may be required for long periods and development of tolerance reduces clinical efficacy of these drugs.
Proglumide has also been shown to act as a δ-opioid agonist, which may contribute to its analgesic effects.
Sicherheitsprofil
Moderately toxic by severalroutes. An experimental teratogen. When heated todecomposition it emits toxic fumes of NOx.
Enzyminhibitor
This anticholinergic agent (FWfree-acid = 334.42 g/mol; CAS 6620-60-6), also known as DL-4-benzamido-N,N-dipropylglutaramic acid and 4- (benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid, is a cholecystokinin receptor antagonist. Proglumide A also exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It finds use clinically as a therapy for gastrointestinal ulcers. Target(s): cholecystokinin receptor; gastrin receptor.
Proglumid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Proglumid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 209)Lieferanten
6620-60-6(Proglumid)Verwandte Suche:
- PROGLUMIDE
- (+/-)-4-benzamido-n,n-dipropylglutaramic acid
- LABOTEST-BB LT00772215
- N(2)-benzoyl-N,N-dipropyl-alpha-glutamine
- 4-(BenzoylaMino)-5-(dipropylaMino)-5-oxo-pentanoic Acid
- 4-BenzaMido-5-(dipropylaMino)-5-oxopentanoic acid
- N-Benzoyl-N′,N′-dipropyl-DL-isoglutamine
- (+-)-pentanoicaci
- 242dl
- binoside
- cr242
- dl-4-benzamido-n,n-dipropylglutaramicacid
- gastrotopic
- kxm
- midelid
- milid
- milide
- n-dipropyl-4-benzamido-dl-glutaramicaci
- nulsa
- promide(parasympatholytic)
- ulcutin
- w5219
- xyde
- xylamide
- xylamide(gastroprotectiveagent)
- 4-benzamido-N,N-dipropyl-DL-glutaramic acid
- PROGLUMIDE SELECTIVE CHOLECYSTOK
- DL-Proglumide
- Glutaramic acid, 4-benzamido-N,N-dipropyl-, DL- (8CI)
- Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo- (9CI)
- Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo-, (+-)-
- PROGUMIDE
- Promid
- Xylamide(gastroprotectite agent)
- D01818
- Nulsa (tn)
- Proglumide (jp15/usan/inn)
- (4R)-4-benzamido-5-(dipropylamino)-5-oxopentanoic acid
- Proglumide USP/EP/BP
- 99% Proglumide
- Factory Supply Bulk Price 99% Proglumide CAS?6620-60-6?with High Quality in Stock
- proglumide(6620-60-6)
- NSC 9416
- NSC9416
- NSC-9416
- ProM
- Proglumide, 10 mM in DMSO
- Proglumide - Bio-X ?
- 6620-60-6
- 620-60-6
- NULSA
- Amines
- Aromatics
- Intermediates & Fine Chemicals
- Pharmaceuticals
