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Adefovir

Adefovir Struktur
106941-25-7
CAS-Nr.
106941-25-7
Englisch Name:
Adefovir
Synonyma:
PMEA;9-[2-(PHOSPHONOMETHOXY)ETHYL]ADENINE;GS-393;gs0393;Adefovi;ADEFOVIR;A Duff Vee;Adefovir98%;Adefovir API;adefovir ,97%
CBNumber:
CB2698137
Summenformel:
C8H12N5O4P
Molgewicht:
273.19
MOL-Datei:
106941-25-7.mol

Adefovir Eigenschaften

Schmelzpunkt:
>260°C
Siedepunkt:
632.5±65.0 °C(Predicted)
Dichte
1.88
storage temp. 
-20°C
L?slichkeit
0.1 M NaOH: ≥5mg/mL
pka
pKa1 2.0, pKa2 6.8(at 25℃)
Aggregatzustand
powder
Farbe
white to beige
InChI
InChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16)
InChIKey
SUPKOOSCJHTBAH-UHFFFAOYSA-N
SMILES
P(COCCN1C2C(N=C1)=C(N)N=CN=2)(=O)(O)O
CAS Datenbank
106941-25-7(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T
R-S?tze: 25
S-S?tze: 45
RIDADR  2811
WGK Germany  3
RTECS-Nr. SZ6563500
HazardClass  6.1
PackingGroup 
HS Code  29339900
Speicherklasse 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
Giftige Stoffe Daten 106941-25-7(Hazardous Substances Data)
Bildanzeige (GHS) Skull and Crossbones (GHS06)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

Adefovir Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Pale Brown Solid

Verwenden

Adefovir has been used to study its anti-retro viral effect on porcine endogenous retrovirus (PERV) activity.

Acquired resistance

It has a lower propensity to induce drug resistance than lamivudine. Clinical trials of patients receiving 48 weeks of therapy did not identify any cases of resistance. Longer courses yield resistant strains of HBV with mutations in the DNA polymerase gene; other rare variants of resistant strains have been identified. Lamivudine-resistant strains of HBV retain susceptibility to adefovir.

Pharmazeutische Anwendungen

A nucleotide analog of adenosine monophosphate, administered orally as its prodrug, adefovir dipivoxil.

Pharmakokinetik

Oral absorption: c. 60%
Cmax 10 mg/kg oral: 18.4 ng/mL
Plasma half-life: c. 7.5 h.
Volume of distribution: 392 mL/kg
Plasma protein binding: Not known
The prodrug is metabolized to adefovir, which is excreted by the kidneys and therefore requires dose adjustment in patients with impaired renal function. It does not induce cytochrome P450 at standard doses and does not influence the metabolism or plasma concentrations of the other licensed medications used in the treatment of hepatitis B.

Clinical Use

Treatment of chronic hepatitis B virus infection in patients >12 years of age

Nebenwirkungen

It is generally well tolerated, with headache, pharyngitis, abdominal pain and peripheral neuropathy being the most common side effects. Nephrotoxicity has been observed in some patients, with those receiving higher doses and longer courses of therapy at greater risk. Exacerbation of hepatitis has been reported in patients immediately following discontinuation of treatment. Most exacerbations occur within 12 weeks of stopping therapy, and elevations of alanine aminotransferase (ALT) up to 10 times the upper limit of normal can be observed in over 25% of patients. Lactic acidosis has been reported in a few patients and is an indication for immediate discontinuation.

Adefovir Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Adefovir Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 413)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Yanxi Chemical Co., Ltd.
+8618531123677
faithe@yan-xi.com China 5853 58
airuikechemical co., ltd.
+86-18353166132
sales02@airuikechemical.com China 983 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29640 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21587 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3619 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29815 58
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715
admin@nexconn.com China 10403 58
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8615060885618
sales@amoychem.com China 6366 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5906 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63687 58

106941-25-7()Verwandte Suche:


  • 2-(6-amino-9h-purin-
  • Adefovir dipivox (PMEA)
  • [[2-(6-AMino-9H-purin-9-yl)ethoxy] Methyl]phosponic Acid
  • P-[[2-(6-AMino-9H-purin-9-yl)ethoxy]Methyl]phosphonic Acid
  • Adefovir(PMEA)
  • Adefovir98%
  • [({[2-(6-aMino-9H-purin-9-yl)ethoxy]Methyl}({[(2,2-diMethylpropanoyl)oxy]Methoxy})phosphoryl)oxy]Methyl 2,2-diMethylpropanoate
  • A Duff Vee
  • Adefovir API
  • GS-393
  • P-[[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic acid, 9-(2-phosphonylmethoxyethyl)adenine
  • 2-(6-Amino-9H-purin-9-yl)ethoxy]methylphosphonic acid Adefovir(PMEA)
  • Adefovir Dipivoxil Impurity (Adefovir)
  • 2-(6-amino-9h-purin-9-yl)ethoxy]methylphosphonic acid
  • 9-(2-PHOSPHONYL METHOXY ETHYL) ADENINE
  • ADEFOVIR
  • ((2-(6-amino-9h-purin-9-yl)ethoxy)methyl)-phosphonicaci
  • 9-[2-(6-Amino-9H-purin-9-yl)ethoxy]methylphosphonicacid
  • [[2-(6-amino-9H-purin-9-yl) ethoxy] methyl] phosphonic acid (PMEA)
  • PMEA([[2-(6-amino-9H-purin-9-yl)
  • 9-[2- (phosphonomethoxy) ethyl] adenine, alternate name adefovir[PMEA]
  • [2-(6-Amino-9H-purine-9-yl)ethoxymethyl]phosphonic acid
  • Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]- (9CI)
  • 9-[2-(6-Amino-9H-purin-9-yl)et
  • Adefovir & Adefovir Dipivoxil
  • gs0393
  • adefovir ,97%
  • 9-[2-[bis(pivaloyloxymethoxy)phosphorylmethoxyl]ethyl]adenine
  • 9-(2-Phosphonomethoxy Etheyl) Adenine
  • 9-(2-PHOSPHORYL METHOXYL ETHYL) ADENINE
  • 9-(2-(2-phosphoromethoxy)ethyl adenine (PMEA)
  • Adefovir dipivoxil intermediate B
  • 2-(6-AMINO-9H-OUR IN-9-YL)ETHOXY]METHYLPHOSPHONIC ACID
  • 9-[2-phosphonylmethoxyethyl]ad
  • Adefovir,9-[2-phosphonylmethoxyethyl]adenine
  • 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE(ADEFOVIR)
  • [[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosponicAcid,PMEA,GS-393,
  • treatment Adefovir
  • Tenofovir Desmethyl Impurity
  • Adefovi
  • Phosphonic acid, P-[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]-
  • Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]-
  • Adefovir USP/EP/BP
  • Adefovir (GS-0393)
  • AdefovirQ: What is Adefovir Q: What is the CAS Number of Adefovir Q: What is the storage condition of Adefovir Q: What are the applications of Adefovir
  • 3-Di-o-tolylguanidine
  • 2-(6-Aminopurin-9-yl)ethoxymethylphosphonic acid
  • Adefovir - Bio-X ?
  • 9-[2-(PHOSPHONOMETHOXY)ETHYL]ADENINE
  • PMEA
  • 106941-25-7
  • C8H12N5O4P
  • C8H14N5O4P
  • C8H13N5O4P
  • Other Products
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
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