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Pirprofen

Pirprofen Struktur
31793-07-4
CAS-Nr.
31793-07-4
Bezeichnung:
Pirprofen
Englisch Name:
Pirprofen
Synonyma:
Su-21524;Pirprofen;Pirprofen USP/EP/BP;PIDSZXPFGCURGN-UHFFFAOYSA-N;3-Chloro-4-(3-pyrrolin-1-yl)hydratropic acid;2-[3-Chloro-4-(3-pyrrolin-1-yl)phenyl]propanoic acid;2-(3-Chloro-4-(2,5-dihydro-1H-pyrrol-1-yl)phenyl)propanoic acid;2-[3-Chloro-4-(2,5-dihydro-1H-pyrrol-1-yl)phenyl]propionic acid;2-[3-Chloro-4-(2,5-dihydro-1H-pyrrole-1-yl)phenyl]propanoic acid;Benzeneacetic acid, 3-chloro-4-(2,5-dihydro-1H-pyrrol-1-yl)-α-methyl-
CBNumber:
CB2875239
Summenformel:
C13H14ClNO2
Molgewicht:
251.71
MOL-Datei:
31793-07-4.mol

Pirprofen Eigenschaften

Schmelzpunkt:
98-100°
Siedepunkt:
410.8±45.0 °C(Predicted)
Dichte
1.1778 (rough estimate)
Brechungsindex
1.5270 (estimate)
storage temp. 
-20°C Freezer, Under inert atmosphere
L?slichkeit
DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
pka
4.56±0.10(Predicted)
Farbe
Off-White

Sicherheit

Pirprofen Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Pirprofen is a non-steroidal anti-inflammatory drug.

Weltgesundheitsorganisation (WHO)

Pirprofen, a nonsteroidal anti-inflammatory agent, was introduced in 1982 primarily for the treatment of rheumatic diseases, as well as for use in posttraumatic and post-operative inflammatory conditions, acute gout and dysmenorrhoea. Reports of serious adverse effects, in particular cases of liver toxicity, some of which were fatal, led the manufacturer, in 1985 and in 1989, to amend the approved product information of the drug, limiting duration of treatment and lowering the recommended doses. In the light of these successive restrictions, which have considerably reduced the field of application of pirprofen and in view of available alternatives, the manufacturer has decided to discontinue the drug worldwide.

Synthese

Synthesis: treatment of the sodium salt of diethyl methylmalonate with 2,4- dichloronitrobenzene yields diethyl (3-chloro- 4-nitrophenyl)methylmalonate. Saponification, decarboxylation, and subsequent reesterification followed by catalytic reduction gives ethyl 4-amino-3-chloro-α-methylbenzeneacetate hydrochloride. Treatment of the latter with 1,4- dichloro-2-butene in the presence of sodium carbonate followed by saponification affords pirprofen.
Pirprofen synthesisPirprofen synthesis

Pirprofen Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Pirprofen Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 19)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 19827 58
Aladdin Scientific

tp@aladdinsci.com United States 57505 58
TargetMol Chemicals Inc.
+17819995354
marketing@targetmol.com United States 19956 58
Shaanxi Dideu New Materials Co. Ltd
+86-18192503167 18192503167
1036@dideu.com China 7915 58
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903
3008007409@qq.com China 89686 60
Shanghai Haohong Pharmaceutical Co., Ltd. 400-8210725 4008210725
malulu@leyan.com China 54995 58
Wuhan pengyin Pharmaceutical Co., Ltd 13163333255
1939328613@qq.com China 395 58
Energy Chemical 021-58432009 400-005-6266
marketing@energy-chemical.com China 44918 58
TargetMol Chemicals Inc. 4008200310 15002144251
marketing@tsbiochem.com China 24955 58
Baoji Didu Pharmaceutical and Chemical Co., Ltd 029-81145305 17791533577
1021@dideu.com China 9999 58

31793-07-4(Pirprofen)Verwandte Suche:


  • Pirprofen
  • 2-[3-Chloro-4-(2,5-dihydro-1H-pyrrol-1-yl)phenyl]propionic acid
  • 2-[3-Chloro-4-(2,5-dihydro-1H-pyrrole-1-yl)phenyl]propanoic acid
  • 2-[3-Chloro-4-(3-pyrrolin-1-yl)phenyl]propanoic acid
  • 3-Chloro-4-(3-pyrrolin-1-yl)hydratropic acid
  • Su-21524
  • PIDSZXPFGCURGN-UHFFFAOYSA-N
  • Benzeneacetic acid, 3-chloro-4-(2,5-dihydro-1H-pyrrol-1-yl)-α-methyl-
  • Pirprofen USP/EP/BP
  • 2-(3-Chloro-4-(2,5-dihydro-1H-pyrrol-1-yl)phenyl)propanoic acid
  • 31793-07-4
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