Apovincamin
|
|
|
- CAS-Nr.
- 4880-92-6
- Bezeichnung:
- Apovincamin
- Englisch Name:
- apovincamine
- Synonyma:
- Apovincamina;apovincamine;Apovincaminum;Vinpocetine-2;Unii-504R182zx7;Einecs 225-491-0;cis-ApovincaMine;(+)-trans-Cavinton;Vincamine Impurity D;Apovincaminum [latin]
- CBNumber:
- CB2890058
- Summenformel:
- C21H24N2O2
- Molgewicht:
- 336.43
- MOL-Datei:
- 4880-92-6.mol
|
Apovincamin Eigenschaften
- Schmelzpunkt:
- 160-162℃
- Siedepunkt:
- 405.7±45.0 °C(Predicted)
- Dichte
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator
- L?slichkeit
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 7.82±0.60(Predicted)
- Farbe
- Off-White to Pale Grey
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung
|
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
|
P264, P270, P301+P312, P330, P501 |
|
| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
|
Apovincamin Chemische Eigenschaften,Einsatz,Produktion Methoden
Originator
Apovincamine,GC Promochem
Manufacturing Process
Apovincamine is semisynthethetic derivative of (+)-vincamine. Vincamine is
alkaloid of Vinca minor. Alcoloid of Tabernaemontana rigida (Apocynaceae)
also is used as raw material for preparing of apovincamine. (+)- Vincamine
was transformed into oxime ester by reaction with NaNO2 in acetic acid at 0°C
-(+/-)-methyl-3-((12bR)-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-
a]quinolizin-1-yl)-2-(hydroxyimino)propanoate, which was resolved on the
isomers with dibenzoyl D-tartratic acid. (-)-Methyl 3-((12bR)-1-ethyl-
1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-1-yl)-2-
(hydroxyimino)propanoate was re-crystallized from methanol to afford (-)-
methyloxime ester, MP: 195°C.
2 g of above oxime methyl ester was heated in mixture of methanol (37.5 ml)
and conc. H2SO4 (13.5 ml) on water bath for 1 hour. The solution was poured
into ice-water (80 ml), basified with conc. NH4OH to pH 9, and extracted with
CH2Cl2 (3x20 ml). The combined extracts were dried (MgSO4), filtered,
evaporated in vacuum and the residue was re-crystallized from MeOH (5 ml)
to yield 1.32 g (72.5%) of (+)-apovincamine, MP: 160°-162°C.
Therapeutic Function
Vasodilator
Apovincamin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Apovincamin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 54)Lieferanten
4880-92-6(Apovincamin)Verwandte Suche:
- Methyl (3alpha,16alpha)-eburnamenine-14-carboxylate
- apovincamine
- Methyl (13aS,13bS)-13a-ethyl-2,3,5,6,13a,13b-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate
- methyl (41S,13aS)-13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate
- (3α,16α)-Eburnamenine-14-carboxylic acid methyl ester
- Apo-14,15-dehydrovincamine
- Apovincaminic acid methyl
- (+)-trans-Cavinton
- Apovincamina
- Apovincamina [spanish]
- Apovincaminum
- Apovincaminum [latin]
- Eburnamenine-14-carboxylic acid, methyl ester, (3-alpha,16-alpha)-
- Einecs 225-491-0
- Methyl (13as,13bs)-13A-ethyl-2,3,4,6,13A,14B-hexahydro-1H-indilol(3.2.1-de)pyrido(3,2,1-ij)(1,5)naphthylridin-12-carboxylat
- Unii-504R182zx7
- Vinpocetine Related Compound B (30 mg) (methyl (13aS,13bS)-13a-ethyl-9-methoxy-2,3,5,6,13a,13b-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate)
- IMp. B (EP): Methyl (13aS,13bS)-13a-Ethyl-2,3,5,6,13a,13b-hexahydro-1H-indolo[3,2,1- de]pyrido[3,2,1-ij][1,5]naphthyridine-12- carboxylate (ApovincaMine)
- Vinpocetine
IMp. B (EP)
- cis-ApovincaMine
- Vinpocetine Related CoMpound B
- Vincamine EP Impurity B
- Vinpocetine EP Impurity B
- methyl (41S,13aS)-13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]phthyridine-12-carboxylate
- Vinpocetine-2
- (41S,13aS)-methyl 13a-ethyl-
- Methyl (13aS,13bS)-13a-Ethyl-2,3,5,
- Vinpocetine impurity B CRS
- Eburnamenine-14-carboxylic acid, methyl ester, (3α,16α)-
- Vinpocetine Related Compound B(Secondary Standards traceble to USP)
- Vinpocetine Related Compound B (Methyl(13aS,13bS)-13a-ethyl-2,3,5,6,13a,13b-hexahydro-1H-indolo[3,2 (1714620)
- Vinpocetine impurity B
(apovincamine)
- Vinpocetine USP Related Compound B
- methyl14,15-didehydrovincane-14-carboxylate(apovincamine)
- methyl(13aS,13bS)-13a-ethyl-2,3,5,6,13a,13b-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate(apovincamine)
- Vincamine EP Impurity D
- (+)-apovincamine, cis-apovincamine
- Methyl (13aS,13bS)-13a-Ethyl-2,3,5,6,13a,13b-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]napht
- Vinpocetine EP Impurity B (Vincamine EP Impurity D)
- Vincamine Impurity D
- 4880-92-6
