adamexine Chemische Eigenschaften,Einsatz,Produktion Methoden
Originator
Adamexine ,ZYF Pharm Chemical
Manufacturing Process
4.3 g 2-brommemtyl-4,6-dibromo-N,N-diacetylaniline and 1.65 g Nmethyladamantyl
amine in 100 ml of absolute ethanol were heated to reflux
for 8 hours. The ethanol was removed and a residue was washed with some
times with ether. The resulting hard mass was refluxed with 150 ml 2 N HCl
for 2 hours. The obtained product was cooled and stood for 10-12 hours at
4°C in a refrigerator. The crystalline 2-(N-(1-adamantyl)-Nmethylaminomethyl-
4',6'-dibromacetanilid hydrochloride (adamexine) was
filtered off and thoroughly washed with distilled water. It was recrystallized
from a mixture glacial acetic acid/water 2:1 (v/v) to give a white crystalline
powder, melting at 250°-254°C. The hydrochloride is better for a
pharmaceutical composition because of solubility in water. The free base may
be prepared by adding of an equivalent of any basic compound (NaOH,
NaHCO3 and so on).
Therapeutic Function
Mucolytic
adamexine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
