BISINDOLYLMALEIMIDE I HYDROCHLORIDE
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- CAS-Nr.
- 176504-36-2
- Englisch Name:
- BISINDOLYLMALEIMIDE I HYDROCHLORIDE
- Synonyma:
- BIS-I HCl;GO-6860 HCl;BIM 1 hydrochloride;GF 109203X hydrochloride >=95%;BisindolylMaleiMide I( Hydrochloride Salt);BisindolylMaleiMide I . hydrochloride [GF-109203K;GF 109203X hydrochloride, ATP-competitive PKC inhibitor;Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem;3-[1-(dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride;3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione
- CBNumber:
- CB2972282
- Summenformel:
- C25H25ClN4O2
- Molgewicht:
- 448.95
- MOL-Datei:
- 176504-36-2.mol
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BISINDOLYLMALEIMIDE I HYDROCHLORIDE Eigenschaften
- storage temp.
- 2-8°C
- L?slichkeit
- DMF: 10 mg/mL; DMSO: 16 mg/mL; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL
- Aggregatzustand
- Orange-red solid
- Farbe
- Orange to red
- Biologische Quelle
- synthetic (organic)
- Wasserl?slichkeit
- water: 10mg/mL
DMSO: 20mg/mL
- InChIKey
- XRAMWNCMYJHGGH-UHFFFAOYSA-N
- SMILES
- Cl.CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c3c[nH]c4ccccc34)c5ccccc15
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| HS Code |
2933998090 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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BISINDOLYLMALEIMIDE I HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible PKC inhibitor (K
i = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine . It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCα, β1, β2, γ, δ, and ε isozymes. BIM I directly inhibits glycogen synthase kinase 3 (GSK3) in primary adipocyte lysates (IC
50 = 360 nM) and in GSK3β immunoprecipitates derived from rat epididymal adipocytes (IC
50 = 170 nM). It also competitively antagonizes the serotonin (5-HT) receptor subtype 5-HT
3 with a K
i value of 61 nM.
Verwenden
GF 109203X hydrochloride has been used to inhibit protein kinase C in human neuroblastoma-derived kelly cells.
Allgemeine Beschreibung
GF 109203X prevents collagen-triggered adenosine and three phosphate (ATP) secretion. It also inhibits collagen and α-thrombin-induced platelet aggregation. It functions as an inhibitor of glycogen synthase kinase-3 (GSK-3). GF 109203X also functions as an anti-inflammatory agent.
BISINDOLYLMALEIMIDE I HYDROCHLORIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
BISINDOLYLMALEIMIDE I HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 40)Lieferanten
176504-36-2()Verwandte Suche:
[1S-[1α,4aα,5α,7α(E),7aα]]-1,4a,5,6,7,7a-Hexahydro-4a,5-dihydroxy-7-methyl-7-[(allyl-1-oxo-3-phenyl)oxy]cyclopenta[c]pyran-1-yl-β-D-glucopyranosid
3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-1-benzopyryliumchlorid
Lup-20(29)-en-3-ol, (3β)-
(2R-trans)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyron
4-Butyl-1,2-diphenyl-3,5-pyrazoli-dindion
- BIM 1 hydrochloride
- 3-[1-(dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride
- BisindolylMaleiMide I( Hydrochloride Salt)
- BisindolylMaleiMide I . hydrochloride [GF-109203K
- 3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride
- 3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione
- Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem
- GF 109203X hydrochloride >=95%
- BIS-I HCl
- GO-6860 HCl
- GF 109203X hydrochloride, ATP-competitive PKC inhibitor
- 3-(1-(3-(Dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride
- 176504-36-2
