HKPao Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
HKPao (Hunter-killer peptide ao) is a biologically active peptide. HKPao (Hunter-killer peptide ao) has anti-obesity and anti-tumor pro-apoptotic activity to cause release of cytochrome c from vesicles.
benefits
Hunter killer peptides (HKPs) use receptor interactions as a vehicle for intracellular delivery and have been reported for targeting angiogenic tumor vasculature, white adipose tissue, and arthritic tissue. These pro-apoptotic peptides contain a variable amino terminal homing sequence, which mediates interactions with cell surface receptors, and a common positively charged carboxyl terminal apoptosis sequence motif that is connected through a glycinyl glycine linker. Once inside the cell, the peptide initiates apoptosis through a membrane perturbing interaction with the mitochondria. The apoptotic sequence is comprised of D-amino acids to increase the in vivo stability.
The amino acids of the pro-apoptotic sequence of HKP1 and HKPao have D-stereochemical configuration and are shown in lower case letters. HKP1 and HKPao can induce leakage of fluorescent dextrans from vesicles that have a larger hydrodyanmic radius than cytochrome c. Similar size dependence profiles suggest that the size of the transient pores formed by both these peptides are the same[1].
HKPao Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
