Nestoron
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- CAS-Nr.
- 7759-35-5
- Englisch Name:
- Nestoron
- Synonyma:
- Segesterone Acetate;NESTORONE;ST 1435;NESTORON;Elcometrine;Nestorone Acetate;Nestoron (ST-1435);Norgestone acetate;Nestoron, 10 mM in DMSO;ELCOMETRINE;NESTORONE;ST-1435;ST1435
- CBNumber:
- CB31011778
- Summenformel:
- C23H30O4
- Molgewicht:
- 370.48
- MOL-Datei:
- 7759-35-5.mol
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Nestoron Eigenschaften
- Schmelzpunkt:
- 178-179°
- alpha
- D21 -105° (c = 1.2 in chloroform)
- Siedepunkt:
- 420.37°C (rough estimate)
- Dichte
- 1.0550 (rough estimate)
- Brechungsindex
- 1.4433 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: soluble5mg/mL, clear
- Aggregatzustand
- powder
- Farbe
- white to beige
- InChI
- InChI=1S/C23H30O4/c1-13-11-21-20-7-5-16-12-17(26)6-8-18(16)19(20)9-10-22(21,4)23(13,14(2)24)27-15(3)25/h12,18-21H,1,5-11H2,2-4H3/t18-,19+,20+,21-,22-,23-/m0/s1
- InChIKey
- CKFBRGLGTWAVLG-GOMYTPFNSA-N
- SMILES
- C1(=O)C=C2[C@]([H])(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)[C@@](OC(C)=O)(C(=O)C)C(=C)C3)CC2
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H351 |
Kann vermutlich Krebs verursachen. |
Karzinogenit?t |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
| H361 |
Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. |
Reproduktionstoxizit?t |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P281 |
Vorgeschriebene pers?nliche Schutzausrüstung verwenden. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Nestoron Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Segesterone Acetate has been used to study the: comparison of androgenic and estrogenic properties of progestins used in contraception and hormone therapy; impact on hepatic estrogen-sensitive proteins by 1-yr contraceptive vaginal ring delivering Nestorone and ethinyl estradiol.
Pharmakokinetik
Elcometrine is a member of the 19-norprogesterone class of pr ogestins. when administered subcuta neously (implant), intravaginally (vaginal ring), or transdermally, elcometrine is an exceptionally potent progestin. It is 100-fold more potent when administered subcutaneously than when delivered orally. Its oral bioavaiability is only 10%，with a half life of just 1 to 2 hours because of rapid metabolism. The C16 methylene functionality substantially increases its affinity for the progesterone receptor.
Clinical Use
Because of its antiestrogenic action, elcometrine also can be administered transdermally along with estradiol as a treatment for menopausal symptoms .
Nestoron Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Nestoron Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 104)Lieferanten
7759-35-5()Verwandte Suche:
- ST 1435
- NESTORON
- 17-Hydroxy-16-methylene-19-norpregn-4-ene-3,20-dione acetate
- Elcometrine
- 17-(ACETYLOXY)-16-METHYLENE-19-NORPREGN-4-ENE-20-DIONE
- 16-Methylene-17-hydroxy-19-norpregn-4-ene-3,20-dione acetate
- 16-Methylene-17-alpha-acetoxy-19-nor-4-pregnene-3,20-dione
- 19-Norpregn-4-ene-3,20-dione, 17-(acetyloxy)-16-methylene- (9ci)
- 19-Norpregn-4-ene-3,20-dione, 17-hydroxy-16-methylene-, acetate
- Nestoron (ST-1435)
- 17-(Acetyloxy)-16-methylene-19-norpregn-4-ene-3,20-dione
- ELCOMETRINE;NESTORONE;ST-1435;ST1435
- (8R,9S,10R,13S,14S,17R)-17-acetyl-13-methyl-16-methylene-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate
- ELCOMETRINE; NESTORONE; ST-1435; ST 1435; ST1435
- 19-Norpregn-4-ene-3,20-dione, 17-(acetyloxy)-16-methylene-
- Estr-4-en-3-one,17-acetyl-17-(acetyloxy)-16-methylene-,(17α)-
- Norgestone acetate
- ST 1435,Inhibitor,Nestoron,ST1435,inhibit,Progesterone Receptor,NR3C3
- Nestorone Acetate
- Nestoron, 10 mM in DMSO
- NESTORONE
- Segesterone Acetate
- 7759-35-5
- API
