FASUDIL
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- CAS-Nr.
- 103745-39-7
- Englisch Name:
- FASUDIL
- Synonyma:
- at877;FASUDIL;Fasudilum;Fasudil HCI;HA-1077：Eril;FASUDIL USP/EP/BP;Fasudil Hydrchloride;Fasudil hydrochlorid;Fasudilum [inn-latin];H-1077 dihydrochloride
- CBNumber:
- CB3101698
- Summenformel:
- C14H17N3O2S
- Molgewicht:
- 291.37
- MOL-Datei:
- 103745-39-7.mol
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FASUDIL Eigenschaften
- Siedepunkt:
- 506.2±60.0 °C(Predicted)
- Dichte
- 1.289±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- L?slichkeit
- H2O: >200 mg/mL
- Aggregatzustand
- solid
- pka
- 9.73±0.20(Predicted)
- Farbe
- white
- Wasserl?slichkeit
- Soluble in water or DMSO
- InChI
- 1S/C14H17N3O2S/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14/h1,3-5,7,11,15H,2,6,8-10H2
- InChIKey
- NGOGFTYYXHNFQH-UHFFFAOYSA-N
- SMILES
- [S](=O)(=O)(N3CCNCCC3)c1c2c(cncc2)ccc1
- CAS Datenbank
- 103745-39-7(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| RTECS-Nr. |
HM4031166 |
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| HS Code |
29334900 |
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| Speicherklasse |
11 - Combustible Solids |
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| Toxizit?t |
mouse,LD50,unreported,73500ug/kg (73.5mg/kg),United States Patent Document. Vol. #4678783, |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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FASUDIL Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White Crystalline Solid
Verwenden
Fasudil is a protein kinase A inhibitor and may be used in medicinal combinations for hepatitis treatment.
Allgemeine Beschreibung
A cell-permeable, reversible, and ATP-competitive Ca
2+ antagonist with anti-vasospastic properties. Inhibits protein kinase A (K
i = 1.6 μM), protein kinase G (K
i = 1.6 μM), and myosin light chain kinase (K
i = 3.6 μM). Also reported to potently inhibit Rho-associated kinase (ROCK; IC
50 = 10.7 μM). Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency.
Biologische Aktivit?t
Cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM). Ca2+ antagonist and vasodilator. Also inhibits proliferation of vascular smooth muscle cells.
FASUDIL Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
FASUDIL Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 199)Lieferanten
103745-39-7()Verwandte Suche:
- Fasudil Hydrochloride Injection
- 1-(5-ISOQUINOLINE-SULFONYL)-HOMOPIPERAZINE
- at877
- hexahydro-1-(5-isoquinolinylsulfonyl)-1h-4-diazepine
- HA-1077 DIHYDROCHLORIDE NOVEL VASODILATO R AGE
- HA 1077, DIHYDROCHLORIDE, 99+%
- FASUDIL
- Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine
- 1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-
- Fasudilum
- Fasudilum [inn-latin]
- HA-1077：Eril
- 2,3,4,5,6,7-Hexahydro-1-(isoquinolin-5-ylsulfonyl)-1H-1,4-diazepine
- 5-(Hexahydro-1H-1,4-diazepine-1-ylsulfonyl)isoquinoline
- H-1077 dihydrochloride
- HA-1077 Dihydrochloride Salt >99%
- 1-(5-Isoquinolinesulfonyl)homopiperazine, Dihydrochloride Salt
- 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline dihydrochloride
- 5-(AZEPAN-4-YLSULFONYL)ISOQUINOLINE DIHYDROCHLORIDE
- Fasudil HCI
- 5-(1,4-diazepan-4-ium-1-ylsulfonyl)isoquinoline
- Fasudil Hydrchloride
- Isoquinoline, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-
- FASUDIL USP/EP/BP
- Fasudil hydrochlorid
- High Quality API Intermediate Fasudil
- (5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE
- HA-1077 (Fasudil) (mM/ml), ROCK2 inhibitor
- 103745-39-7
- C14H17N3O2S2HCl
- C14H17N3O2S2ClH
- Signalling
- Protein Kinase Inhibitors and Activators
- Protein Kinase
- Angiogenesis and Metastasis
- Intracellular signaling
- ERIL
- APIs
