1-(1H-indol-4-yloxy)-3-((1-methyl-ethyl)amino)-2-propanol
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- CAS-Nr.
- 13523-86-9
- Bezeichnung:
- 1-(1H-indol-4-yloxy)-3-((1-methyl-ethyl)amino)-2-propanol
- Englisch Name:
- Pindolol
- Synonyma:
- lb46;LB-46;Visken;Vasken;dl-lb46;Decreten;Pinbetol;Pynastin;PINDOLOL;(+-)-lb46
- CBNumber:
- CB3105373
- Summenformel:
- C14H20N2O2
- Molgewicht:
- 248.32
- MOL-Datei:
- 13523-86-9.mol
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1-(1H-indol-4-yloxy)-3-((1-methyl-ethyl)amino)-2-propanol Eigenschaften
- Schmelzpunkt:
- 167-171 °C(lit.)
- Siedepunkt:
- 391.39°C (rough estimate)
- Dichte
- 1.0606 (rough estimate)
- Brechungsindex
- 1.5110 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- 0.1 M NaOH: 0.2 mg/mL
- Aggregatzustand
- powder
- pka
- pKa 9.26 (Uncertain)
- Farbe
- white to off-white
- Wasserl?slichkeit
- 33mg/L(22.5 ºC)
- Merck
- 13,7525
- Major Application
- pharmaceutical (small molecule)
- InChI
- InChI=1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3
- InChIKey
- JZQKKSLKJUAGIC-UHFFFAOYSA-N
- SMILES
- C(OC1=CC=CC2=C1C=CN2)C(O)CNC(C)C
- CAS Datenbank
- 13523-86-9(CAS DataBase Reference)
- NIST chemische Informationen
- Pindolol(13523-86-9)
- EPA chemische Informationen
- 2-Propanol, 1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]- (13523-86-9)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22-36/37/38 |
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| S-S?tze: |
26-36 |
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| RIDADR |
3249 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
UB6660000 |
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| HazardClass |
6.1(b) |
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| PackingGroup |
III |
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| HS Code |
2933995300 |
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| Speicherklasse |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications |
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
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| Giftige Stoffe Daten |
13523-86-9(Hazardous Substances Data) |
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| Toxizit?t |
LD50 oral in rabbit: 650mg/kg |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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1-(1H-indol-4-yloxy)-3-((1-methyl-ethyl)amino)-2-propanol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White Solid
Verwenden
Pindolol, like nadolol, is a nonselective β-adrenoblocker. It possesses antianginal, antihypotensive, and antiarrythmic action. It is used for arterial hypertension, angina stress (preventing attacks), supraventricular tachycardia, tachsystolic form of atrial fibrillation, and
superventricular extrasystole.
Definition
ChEBI: A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.
Biologische Aktivit?t
5-HT 1A/1B receptor antagonist, with roughly equal affinity for each subtype. A partial agonist at mouse and human β 3 -adrenoceptors.
Stoffwechselwegen
Several metabolites of pindolol formed in vitro are
detected after a 24 h incubation of human hepatocytes
in both pure culture and co-culture by adding rat liver
epithelial cells. The hepatocytes are able to oxidize
the isopropyl amine moiety and the pyrrole ring of the
indole moiety and conjugate pindolol as sulfates and
glucuronides.
Stoffwechsel
Pindolol (Visken) is extensively absorbed from the
gastrointestinal tract. First-pass metabolism is estimated
at about 15%, and its plasma half-life is on the order of
3 to 4 hours.The binding of pindolol to plasma proteins
is approximately 50%.The metabolic fate of pindolol is
not completely understood, although 50% of an administered
dose is recovered, primarily in the urine, as unchanged
drug.
1-(1H-indol-4-yloxy)-3-((1-methyl-ethyl)amino)-2-propanol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1-(1H-indol-4-yloxy)-3-((1-methyl-ethyl)amino)-2-propanol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 122)Lieferanten
13523-86-9(1-(1H-indol-4-yloxy)-3-((1-methyl-ethyl)amino)-2-propanol)Verwandte Suche:
- (+-)-4-(2-hydroxy-3-(isopropylamino)propoxy)indole
- (+-)-lb46
- (rs)-pindolol
- carvisken
- Decreten
- dl-4-(2-hydroxy-3-(isopropylamino)propoxy)indole
- dl-lb46
- dl-pindolol
- Durapindol
- Glauco-visken
- glauco-viskin
- lb46
- LB-46
- Pectobloc
- Pinbetol
- Prinodolol
- Pynastin
- 1-(1H-INDOL-4-YLOXY)-3-[(1-METHYLETHYL)AMINO]-2-PROPANOL
- 1-[1H-INDOL-4-YLOXY]-3-[ISOPROPYLAMINO]-2-PROPANOL
- 1-(INDOL-4-YLOXY)-3-(ISOPROPYLAMINO)-2-PROPANOL
- PINDOLOL
- 1-((1-methylethyl)amino)-3-(4-indolyloxy)-2-propanol
- 1-(1h-indol-4-yloxy)-3-((1-methylethyl)amino)-2-propano
- 1-(4-indolyloxy)-3-(isopropylamino)-2-propano
- 1-(4-Indolyloxy)-3-(isopropylamino)-2-propanol
- 2-Propanol, 1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]-
- 2-Propanol, 1-(4-indolyloxy)-3-(isopropylamino)-
- 4-(2-Hydroxy-3-isopropylaminopropoxy)-indole
- 4-(3-(isopropylamino)-2-hydroxypropoxy)indole
- 4-[2-hydroxy-3-(isopropylamino)-propoxy]indole
- Betapindol
- Blockin L
- Blocklin L
- blocklinl
- Calvisken
- Cardilate
- Visken
- PINDOLOL 97%
- PINDOLOL VASODILATOR
- PINDOLOL,USP
- 2-Propanol, 1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]- (9CI)
- 2-Propanol, 1-(indol-4-yloxy)-3-(isopropylamino)- (8CI)
- N-[2-Hydroxy-3-(1H-indol-4-yloxy)propyl]-N-isopropylamine
- Vasken
- Pindolol & 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
- Pindolol,1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol, 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
- Pindolol (200 mg)
- 1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol, 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
- 1-(1H-Indol-4-yloxy)-3-[(1-Methylethyl)aMino]-
- Pindolol (1539701)
- PindololQ: What is
Pindolol Q: What is the CAS Number of
Pindolol Q: What is the storage condition of
Pindolol Q: What are the applications of
Pindolol
- Pindolol (LB-46)
- Pindolol USP/EP/BP
- Pindolol CRS
- C16209000 Pindolol
- Indololol
- Pindolol, 5-HT1A and 5-HT1B receptor antagonist
- Pindolol Intermediate
