Marimastat
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- CAS-Nr.
- 154039-60-8
- Englisch Name:
- Marimastat
- Synonyma:
- TMH;GI 5712;BB 2516;TA 2516;CS-1627;KB-R 8898;Marimastat;Marimistat;Marimastat(BB-2516);BB 2516; MARIMISTAT
- CBNumber:
- CB31073538
- Summenformel:
- C15H29N3O5
- Molgewicht:
- 331.41
- MOL-Datei:
- 154039-60-8.mol
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Marimastat Eigenschaften
- Schmelzpunkt:
- 148℃
- Dichte
- 1.140±0.06 g/cm3(Predicted)
- RTECS-Nr.
- EJ6665000
- storage temp.
- -20°C
- L?slichkeit
- DMSO: ≥20mg/mL
- Aggregatzustand
- White solid
- pka
- 9.44±0.40(Predicted)
- Farbe
- White to gray
- InChI
- 1S/C15H29N3O5/c1-8(2)7-9(10(19)13(21)18-23)12(20)17-11(14(22)16-6)15(3,4)5/h8-11,19,23H,7H2,1-6H3,(H,16,22)(H,17,20)(H,18,21)/t9-,10+,11-/m1/s1
- InChIKey
- OCSMOTCMPXTDND-OUAUKWLOSA-N
- SMILES
- CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C
Marimastat Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Marimastat acts as a matrix metalloproteinase inhibitor in the treatment of various cancers, and pathological occurrences such as arthritis and atherosclerosis.
Allgemeine Beschreibung
An orally active peptidyl hydroxamate-based broad-spectrum MMP inhibitor (IC
50 in nM = 5, 6, 200, 20, 2, 1.8 and 3.8 for MMP-1, -2, -3, -7, -8, -14 and TACE, respectively) that targets both the substrate binding site and the active-site Zn
2+. Marimastate is widely used in studying the involvement of MMPs in various cellular and pathological processes both
in vitro and
in vivo.
Biologische Aktivit?t
Broad spectrum inhibitor of matrix metalloprotease (MMP) (IC 50 values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). In vivo inhibits peritoneal dissemination of human gastric cancer cells through inhibition of tumor angiogenesis.
Marimastat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Marimastat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 138)Lieferanten
154039-60-8()Verwandte Suche:
- Marimastat
- (2R,3S)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-N4,3-dihydroxy-2-isobutylsuccinamide
- (2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide
- (2R,3S)-N1-((S)-3,3-diMethyl-1-(MethylaMino)-1-oxobutan-2-yl)-N4
- BB 2516
- GI 5712
- KB-R 8898
- TA 2516
- Marimastat(BB-2516)
- BB2516, (2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl] propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide
- (2R,3S)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N\',3-dihydroxy-2-(2-methylpropyl)butanediamide
- BB 2516; MARIMISTAT
- Marimistat
- CS-1627
- Butanediamide, N4-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)-, (2S,3R)-
- BB2516|||KB-R8898|||TA2516
- Marimastat, Matrix metalloprotease (MMP) inhibitor
- Marimastat, 10 mM in DMSO
- TMH
- 154039-60-8
- C15H29N3O5
- API
