5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione

764667-64-3

CAS-Nr.: 764667-64-3

Englisch Name:: 5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione

Synonyma:: ethylidene);Sitagliptin-9;Sitagliptin Impurity 96;5-(1-Hydroxy-2-(2,4,5-trifluorophenyl);5-[1-Hydroxy-2-(2,4,5-trifluorophenyl)et;5-[1-hydroxy-2-92,4,5-trifluorophenyl0ethylidene]-2,2-dimethyl;5-[1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-dimeth...;5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione;5-[1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-diMethyl-1,3-dioxane-4,6-dion;3-(trisFluoroMethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

CBNumber:: CB31120915

Summenformel:: C14H11F3O5

Molgewicht:: 316.23

MOL-Datei:: 764667-64-3.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 100

5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione Eigenschaften

Schmelzpunkt:: 117 °C (decomp)

Siedepunkt:: 489.0±45.0 °C(Predicted)

Dichte: 1.462±0.06 g/cm3(Predicted)

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C

L?slichkeit: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

Aggregatzustand: Solid

pka: 4.50±1.00(Predicted)

Farbe: White to Off-White

Sicherheit

Risiko- und Sicherheitserkl?rung
Gefahreninformationscode (GHS)

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	P-Code
H302	Gesundheitssch?dlich bei Verschlucken.	Akute Toxizit?t oral	Kategorie 4	Warnung	P264, P270, P301+P312, P330, P501
H315	Verursacht Hautreizungen.	Hautreizung	Kategorie 2	Warnung	P264, P280, P302+P352, P321,P332+P313, P362
H319	Verursacht schwere Augenreizung.	Schwere Augenreizung	Kategorie 2	Warnung	P264, P280, P305+P351+P338,P337+P313P
H335	Kann die Atemwege reizen.	Spezifische Zielorgan-Toxizit?t (einmalige Exposition)	Kategorie 3 (Atemwegsreizung)	Warnung

Sicherheit

P261	Einatmen von Staub vermeiden.
P305+P351+P338	BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

White to Off-white Solid.

Verwenden

5-[1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione is an impurity of the DPP-IV inhibitor Sitagliptin (S491000).

Application

5-[1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene] is an intermediate for the synthesis of sitagliptin. Sitagliptin is a new type of anti-type II diabetes drug approved by the FDA and the first dipeptidyl peptidase-IV inhibitor drug for the treatment of type II diabetes.

5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione Upstream-Materialien And Downstream Produkte

Upstream-Materialien

2,2-Dimethyl-1,3-dioxan-4,6-dion 2,4,5-Trifluorophenylacetic acid N,N-Dimethylpyridin-4-amin Ethyldiisopropylamin Pivaloylchlorid Hydrogenchlorid

Downstream Produkte

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate (Z)-Methyl 3-aMino-4-(2,4,5-trifluorophenyl)but-2-enoate Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)-

5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 100)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21586	55
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	340	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	28509	58
AFINE CHEMICALS LIMITED	+86-571-85134551	info@afinechem.com	China	15083	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52704	58
Hangzhou Huarong Pharm Co., Ltd.	571-86758373 +8613588754946	sales@huarongpharm.com	CHINA	3148	58

764667-64-3()Verwandte Suche:

2,2-Dimethyl-1,3-dioxan-4,6-dion Natrium octadecylfumarat 1,1-Dichlorethen 2,4-Difluorphenylessigsure Ethyltrifluoracetat 3,4-Difluorphenylessigsure

5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione
5-[1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-diMethyl-1,3-dioxane-4,6-dion
5-[1-hydroxy-2-92,4,5-trifluorophenyl0ethylidene]-2,2-dimethyl
1,3-Dioxane-4,6-dione,5-[1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-diMethyl-
5-[1-Hydroxy-2-(2,4,5-trifluorophenyl)-4,6-dionethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione
5-(1-Hydroxy-2-(2,4,5-trifluorophenyl)
ethylidene)
Sitagliptin Impurity 96
Sitagliptin impurity 42/Sitagliptin Dioxo Impurity/5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl- 1,3-dioxane-4,6-dione
Sitagliptin-9
5-[1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-dimeth...
5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione 764667-64-3
5-[1-Hydroxy-2-(2,4,5-trifluorophenyl)et
5-(1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione (Sitagliptin Impurity)
3-(trisFluoroMethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
764667-64-3
Aromatics
Heterocycles
Impurities
Intermediates

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