N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride
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- CAS-Nr.
- 1177141-67-1
- Englisch Name:
- N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride
- Synonyma:
- CKI-7 Dihydrochloride;CKI-7 2HCL;CKI-7 dihydrochlorid;CKI-7, 10 mM in DMSO;CKI-7 (hydrochloride);CKI-7 dihydrochloride[C0742];N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide dihydrochloride;N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride;Serum and glucocorticoid-regulated kinase,inhibit,nestin,S6K,Inhibitor,CK1,Casein Kinase,Ribosomal S6 Kinase (RSK),differentiation,SGK,CKI-7,Cyclin dependent kinase,neural,Serum-glucocorticoid regulated kinase,S6K1,MSK1,CDK,CKI 7,Wnt,CKI7,βIII-tubulin,Sox1
- CBNumber:
- CB31176497
- Summenformel:
- C11H14Cl3N3O2S
- Molgewicht:
- 358.67176
- MOL-Datei:
- 1177141-67-1.mol
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N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride Eigenschaften
- Schmelzpunkt:
- 187-189°C
- storage temp.
- -20°C
- L?slichkeit
- H2O: >5mg/mL
- Aggregatzustand
- solid
- Farbe
- white to light tan
- Wasserl?slichkeit
- H2O: >5mg/mL
- InChI
- 1S/C11H12ClN3O2S.2ClH/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10;;/h1-3,5,7,15H,4,6,13H2;2*1H
- InChIKey
- JUAVTXYOCISSSL-UHFFFAOYSA-N
- SMILES
- Cl[H].Cl[H].NCCNS(=O)(=O)c1ccc(Cl)c2ccncc12
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
T |
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| R-S?tze: |
25 |
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| S-S?tze: |
45 |
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| RIDADR |
UN 2811 6.1 / PGIII |
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| WGK Germany |
3 |
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| Speicherklasse |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications |
Acute Tox. 3 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
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P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Beige Solid
Verwenden
Found to have a potent inhibitory action against casein kinase 1 completely with respect to ATP and a much weaker effect on casein kinase 2 and other protein kinases
Biochem/physiol Actions
CKI-7 is a CK1 inhibitor; also inhibits SGK, S6K1 and MSK1. CKI-7 inhibits SGK as potently as CK1. IC50 = 6 μM.
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 80)Lieferanten
- N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride
- CKI-7 dihydrochlorid
- N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide dihydrochloride
- CKI-7 2HCL
- Serum and glucocorticoid-regulated kinase,inhibit,nestin,S6K,Inhibitor,CK1,Casein Kinase,Ribosomal S6 Kinase (RSK),differentiation,SGK,CKI-7,Cyclin dependent kinase,neural,Serum-glucocorticoid regulated kinase,S6K1,MSK1,CDK,CKI 7,Wnt,CKI7,βIII-tubulin,Sox1
- CKI-7 (hydrochloride)
- CKI-7, 10 mM in DMSO
- CKI-7 dihydrochloride[C0742]
- CKI-7 Dihydrochloride
- 1177141-67-1
- C11H14Cl3N3O2S
- Inhibitors
- Protein Kinase Inhibitors and Activators
- All Inhibitors
