Salbutamol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
S-S?tze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Albuterol is a β2-adrenergic sympathomimetic amine with pharmacological similarities to
terbutaline. It has almost no effect on β1-adrenoreceptors of the heart. It has expressed
broncholytic effects—prevention or relief of bronchi spasms, lowering respiratory tract
resistance, and increasing the vital capacity of the lungs.
Chemische Eigenschaften
solid
History
In 1968, Salbutamol (Albuterol) will become the most prescribed bronchodilator in the world. Discovered by DAVID HARTLEY, DAVID JACK, LAWRENCE LUNTZ AND ALEXANDER RITCHIE of the British company Allen and Hanburys, former division of Glaxo-smith kline marketed under the name of Ventolin; who will stop the acute crisis and save the life of the asthmatic.
In 2008, a study shows its action in cases of neuromuscular diseases.
In February 2020, the U.S. Food and Drug Administration (FDA) approved the first generic of an albuterol sulfate inhalation aerosol for the treatment or prevention of bronchospasm in people four years of age and older with reversible obstructive airway disease and the prevention of exercise-induced bronchospasm in people four years of age and older. The FDA granted approval of the generic albuterol sulfate inhalation aerosol to Perrigo Pharmaceutical.
Verwenden
immune suppressant, antineoplastic, antiviral
Definition
ChEBI: A member of the class of phenylethanolamines that is 4-(2-amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol having a tert-butyl group attached to the nirogen atom. It acts as a beta-adrenergic agonist used in the treatment of asthma
and chronic obstructive pulmonary disease (COPD).
Biologische Funktion
Levalbuterol is the R-(–)-isomer of albuterol and is available only in solution to be administered via nebulizer. Because it is the active isomer, the dose is fourfold less than that of albuterol. Pirbuterol is the pyridine isostere of albuterol. It has pharmacokinetics similar to albuterol but is half as potent at the β2-receptor. Pirbuterol is only available as an inhaler, whereas albuterol comes in tablet, syrup, solution, and aerosol formulations.
Allgemeine Beschreibung
Standard for Supelco MIP SPE cartridges. For more information request Supelco Literature T407075, T706019, T706030, T706020. Salbutamol is classified under the β-agonist group of chemicals which are known to possess powerful pharmacological activities.
Clinical Use
Albuterol has the N-t-butyl and a salicyl alcohol phenyl ring, which gives it optimal β2-selectivity. It is resistant to COMT and slowly metabolized by MAO, giving it good oral bioavailability. Its onset by inhalation is within 5 minutes, with a duration of action between 4 and 8 hours. It currently is the drug of choice for relief of the acute bronchospasm of an asthmatic attack.
Nebenwirkungen
Adverse effects of pirbuterol are nervousness, tremor, and headache, which is less than the profile for albuterol, which adds nausea, vomiting, dizziness, hypertension, insomnia, tachycardia, and palpitations.
Environmental Fate
Tachycardia occurs as a reflex to the drop in mean arterial
pressure (MAP) or as a result of b-1 stimulus. b-Adrenergic
receptors in the locus coeruleus also regulate norepinephrineinduced
inhibitory effects, resulting in agitation, restlessness,
and hand tremor. Stimulation of nonpulmonary b2 receptors
may lead to an increase in heart rate, QTc interval prolongation,
nonspecific T-wave changes, skeletal muscle tremor, and slight
increases in blood glucose and nonesterified fatty acids. Hypokalemia
is more pronounced in patients receiving intravenous
albuterol. Hypotension is also known to occur mostly in overdose.
The buildup of cyclic AMP in the liver stimulates glycogenolysis
and an increase in serum glucose.
In skeletal muscle, this process results in increased lactate
production. Direct stimulus of sodium/potassium ATPase in
skeletal muscle produces a shift of potassium from the extracellular
space to the intracellular space. Relaxation of smooth
muscle produces a dilation of the vasculature supplying skeletal
muscle, which results in a drop in diastolic and MAP.Myocardial ischemia and infarction have been associated with
excessive tachycardia in elderly patients. The skin may be warm
and pink with evidence of diaphoresis.
Salbutamol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
