brusatol
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- CAS-Nr.
- 14907-98-3
- Englisch Name:
- brusatol
- Synonyma:
- Brustaol;100935;Yatansin;Brusato1;NSC 172924;(+)-Brusatol;Brusatol - Bio-X ?;Brusatol >=95% (HPLC);Brusatol (NSC 172924);Brusatol, 10 mM in DMSO
- CBNumber:
- CB31342731
- Summenformel:
- C26H32O11
- Molgewicht:
- 520.53
- MOL-Datei:
- 14907-98-3.mol
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brusatol Eigenschaften
- Siedepunkt:
- 724.3±60.0 °C(Predicted)
- Dichte
- 1.46±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- -20°C
- L?slichkeit
- DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
- Aggregatzustand
- powder
- pka
- 8.81±0.70(Predicted)
- Farbe
- white to beige
- Biologische Quelle
- (Brucia javanica)
- Optische Rotation
- [α]/D +35 to +44°, c = 0.5 in acetone
- InChIKey
- ZZZYHIMVKOHVIH-YHSWLYNENA-N
- SMILES
- CC1=C(O)C(C[C@@]2(C)[C@@]1([H])C[C@]3([H])[C@]45[C@]2([H])[C@@H](O)[C@H](O)[C@](OC5)(C(OC)=O)[C@]4([H])[C@@H](OC(C=C(C)C)=O)C(O3)=O)=O
- LogP
- 0.393 (est)
brusatol Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Brusatol has been used to study the protective role of Nrf2 (nuclear factor, erythroid 2 like 2 ) in intestinal ischemia/reperfusion induced injury.
Biochem/physiol Actions
Brusatol promotes Nrf2 (nuclear factor, erythroid 2 like 2 ) ubiquitination and degradation. Brusatol upregulates the expression of multiple ribosomal components and controls macromolecular complex function.
brusatol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
brusatol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 178)Lieferanten
14907-98-3()Verwandte Suche:
- 13,20-Epoxy-3,11β,12α-trihydroxy-15β-[(3-methyl-1-oxo-2-butenyl)oxy]-2,16-dioxopicras-3-en-21-oic acid methyl ester
- 13,20-Epoxy-3,11β,12α-trihydroxy-15β-[(3-methyl-1-oxo-2-butenyl)oxy]-2,16-dioxopicrasa-3-ene-21-oic acid methyl ester
- Picras-3-en-21-oicacid,13,20-epoxy-3,11,12-trihydroxy-15-[(3-Methyl-1-oxo-2-buten-1-yl)oxy]-2,16-dioxo-,Methyl ester, (11b,12a,15b)-
- NSC 172924
- Yatansin
- Picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-[(3-methyl-1-oxo-2-buten-1-yl)oxy]-
- Brusatol (NSC 172924)
- (1R,2S,3S,3aS,3a1R,4R,6aR,7aR,11aS,11bR)-Methyl 1,2,9-trihydroxy-8,11a-dimethyl-4-((3-methylbut-2-enoyl)oxy)-5,10-dioxo-2,3,3a,4,5,6a,7,7a,10,11,11a,11b-dodecahydro-1H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-3-carboxylate
- (+)-Brusatol
- Brusatol >=95% (HPLC)
- Picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-[(3-methyl-1-oxo-2-buten-1-yl)oxy]-2,16-dioxo-, methyl ester, (11β,12α,15β)-
- Brusato1
- 100935
- methyl (1R,2S,3S,3aS,3a1R,4R,6aR,7aR,11aS,11bR)-1,2,9-trihydroxy-8,11a-dimethyl-4-((3-methylbut-2-enoyl)oxy)-5,10-dioxo-1,4,5,6a,7,7a,10,11,11a,11b-decahydro-2H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-3(3aH)-carboxylate
- Brusatol, 10 mM in DMSO
- Brusatol - Bio-X ?
- Brustaol
- 14907-98-3
