ORGANOPHOSPHATES Chemische Eigenschaften,Einsatz,Produktion Methoden
Pharmakologie
The organophosphate compounds also react at the esteratic
site of AChE.In general, however,
they are much less selective than are the carbamates, inhibiting
many enzymes that contain a serine molecule at
an active center. The organophosphate compounds
have this general structure:
Parathion
and malathion (insecticides) are thiophosphates that must be converted to oxyanalogues to become active.
The organophosphates, except for echothiophate,
are very lipid soluble.In the interaction of isoflurophate with AChE, a
phosphorylated intermediate is formed and fluoride is
released.An important characteristic of the organophosphate-
induced inhibition is that the bond between the
phosphate and the enzyme is very stable.While the regeneration
of most carbamylated enzymes occurs with a
half-life of minutes or hours, the recovery of a phosphorylated
enzyme is generally measured in days. These
agents are referred to, therefore, as irreversible inhibitors.
ORGANOPHOSPHATES Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
