Trovafloxacin Mesylate
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- CAS-Nr.
- 147059-75-4
- Englisch Name:
- Trovafloxacin Mesylate
- Synonyma:
- Trovan;CP 99219-27;Unii-0p1lko80wn;Trovafloxacin MonoMeth;Trovafloxacin Methanesulfonate;Trifenoxacin Methanesulfonic Acid;Trovafloxacin monomethanesulfonate;147059-75-4 Trovafloxacin mesylate;Trovafloxacin mesylate, 10 mM in DMSO;Trovafloxacin mesylate - CP 99219 mesylate
- CBNumber:
- CB31456463
- Summenformel:
- C21H19F3N4O6S
- Molgewicht:
- 512.46
- MOL-Datei:
- 147059-75-4.mol
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Trovafloxacin Mesylate Eigenschaften
- Schmelzpunkt:
- >250°C (dec.)
- storage temp.
- room temp
- L?slichkeit
- DMSO: >10mg/mL
- Aggregatzustand
- powder
- Farbe
- white to off-white
- InChIKey
- DYNZICQDCVYXFW-AHZSKCOENA-N
- SMILES
- S(O)(=O)(=O)C.O=C1C(=CN(C2C=CC(F)=CC=2F)C2=NC(N3C[C@@]4([H])[C@H](N)[C@@]4([H])C3)=C(F)C=C12)C(=O)O |&1:23,25,27,r|
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
C |
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| R-S?tze: |
63-34 |
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| S-S?tze: |
26-36-45 |
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| RIDADR |
UN 1759 8 / PGIII |
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| WGK Germany |
3 |
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| RTECS-Nr. |
QN2791250 |
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| Speicherklasse |
8A - Combustible corrosive hazardous materials |
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| Hazard Classifications |
Repr. 2
Skin Corr. 1B |
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| Toxizit?t |
women,LDLo,oral,2mg/kg (2mg/kg),SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE",Archives of Internal Medicine. Vol. 159, Pg. 2225, 1999. |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H314 |
Verursacht schwere Ver?tzungen der Haut und schwere Augensch?den. |
?tzwirkung auf die Haut |
Kategorie 1B |
Achtung |
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P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501 |
| H361 |
Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. |
Reproduktionstoxizit?t |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P330+P331 |
BEI VERSCHLUCKEN: Mund ausspülen. KEIN Erbrechen herbeiführen. |
| P303+P361+P353 |
BEI BERüHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Trovafloxacin Mesylate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Trovafloxacin is a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in bacteria by blocking the activity of topoisomerase IV (IC
50 = 3.02 μg/ml) and DNA gyrase (IC
50 = 7.13 μg/ml).
Chemische Eigenschaften
White Solid
Verwenden
Fluorinated quinolone antibacterial. Trovafloxacin mesylate blocks the activity of DNA gyrase and topoisomerase IV, enzymes essential in the repliction, transcription, and repair of bacterial DNA.
Definition
ChEBI: A methanesulfonate (mesylate) salt prepared from equimolar amounts of trovafloxacin and methanesulfonic acid. A broad-spectrum antibiotic that was withdrawn from the market due to risk of liver failure.
Biologische Aktivit?t
Fluoroquinolone antibiotic. Inhibits bacterial DNA topoisomerase IV and DNA gyrase and forms a stable quinolone-DNA complex with these enzymes which reversibly inhibits DNA synthesis. Displays potent activity against gram-positive and gram-negative bacteria.
Trovafloxacin Mesylate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Trovafloxacin Mesylate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 90)Lieferanten
- 7-[(1α,5α,6α)-6-AMino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Methanesulfonate
- CP 99219-27
- 7-[(1S,5R)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid
- Trovafloxacin monomethanesulfonate
- Trovan
- Unii-0p1lko80wn
- 7-[(1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylicacidmesylate
- Trovafloxacin Methanesulfonate
- Trovafloxacin MonoMeth
- (1α,5α,6α)-7-(6-Amino-3-azabicyclo[3.1.0]hex-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid methanesulfonate
- Trovafloxacin mesylate - CP 99219 mesylate
- 147059-75-4 Trovafloxacin mesylate
- topoisomerase-IV,TNF,gyrase,Bacterial,hepatotoxicity,LPS,Trovafloxacin,broad-spectrum,Trovafloxacin mesylate,Antibiotic,DNA,Inhibitor,PANX1,Topoisomerase,pneumococci,inhibit,pro-inflammatory,NF-κB
- 1,8-Naphthyridine-3-carboxylic acid, 7-[(1α,5α,6α)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, methanesulfonate (1:1)
- rel-7-((1R,5S,6s)-6-Amino-3-azabicyclo[3.1.0]hexan-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid compound with methanesulfonic acid (1:1) , Trovafloxacin mesylate
- rel-7-((1R,5S,6s)-6-Amino-3-azabicyclo[3.1.0]hexan-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid compound with methanesulfonic acid (1:1)
- Trovafloxacin mesylate, Fluoroquinolone antibiotic agent
- Trovafloxacin mesylate, 10 mM in DMSO
- Trifenoxacin Methanesulfonic Acid
- 147059-75-4
- C21H19F3N4O6S
- C20H15F3N4O3CH3SO3H
- Amines
- Chiral Reagents
- Heterocycles
- Intermediates & Fine Chemicals
- Pfizer compounds
- Pharmaceuticals
