5,12-dihydroquinoxalino[2,3-b]quinoxaline

531-46-4

CAS-Nr.: 531-46-4

Englisch Name:: 5,12-dihydroquinoxalino[2,3-b]quinoxaline

Synonyma:: Fluoflavine;ML-090;5,12-dihydroquinoxalino[2,3-b]quinoxaline;6,11-dihydroquinoxalino[2,3-b]quinoxaline;Quinoxalino[2,3-b]quinoxaline, 5,11-dihydro-;5,12-Dihydroquinoxalino[2,3-b]quinoxaline (~90%);NOX4,ML090,NADPH Oxidase,Inhibitor,NOX,HEK293 cell,NOX3,ML 090,NOX2,inhibit,ML-090,NOX1

CBNumber:: CB31549066

Summenformel:: C14H10N4

Molgewicht:: 234.26

MOL-Datei:: 531-46-4.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 33

5,12-dihydroquinoxalino[2,3-b]quinoxaline Eigenschaften

Schmelzpunkt:: >262°C (dec.)

Siedepunkt:: 450.2±28.0 °C(Predicted)

Dichte: 1.43±0.1 g/cm3(Predicted)

storage temp.: -20°C Freezer

L?slichkeit: DMSO (Slightly, Heated, Sonicated)

Aggregatzustand: Solid

pka: 3.94±0.20(Predicted)

Farbe: Off-White to Dark Yellow

InChI: InChI=1S/C14H10N4/c1-2-6-10-9(5-1)15-13-14(16-10)18-12-8-4-3-7-11(12)17-13/h1-8H,(H,15,17)(H,16,18)

InChIKey: WGKYYZDYHYOKQV-UHFFFAOYSA-N

SMILES: N1C2=C(C=CC=C2)N=C2NC3=C(N=C12)C=CC=C3

Sicherheit

5,12-dihydroquinoxalino[2,3-b]quinoxaline Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

NADPH oxidase 1 (NOX1) generates reactive oxygen species (ROS) in colon epithelial cells that interacts with both pathogenic and normal bacteria. Excess ROS production, however, is associated with damage to the intestinal mucosa, inflammatory bowel disease, and prostate cancer. ML-090 is the first identified NOX1-specific inhibitor (IC₅₀ = 360 nM in HEK293 cells) based on a quinoxaline scaffold that demonstrates potent selectivity over NOX2, NOX3, and NOX4 (IC₅₀s ≥ 10 μM) and xanthine oxidase (IC₅₀ = 3.5 μM).

Verwenden

5,12-Dihydroquinoxalino[2,3-b]quinoxaline is an inhibitor ofNADPH oxidase 1 (NOX1).

5,12-dihydroquinoxalino[2,3-b]quinoxaline Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

5,12-dihydroquinoxalino[2,3-b]quinoxaline Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 33)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
Aladdin Scientific		tp@aladdinsci.com	United States	52923	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9804	58
Zhengzhou Huiju Chemical Co., Ltd.	0371-55900031 18137872243	3927209986@qq.com	China	10000	55
Shanghai TenSus Biotechnology Co., Ltd.	021-50895067 18616507272	tensus@163.com	China	8031	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
ShangHai ChuanQian Chemcial Technique Centre	15869524721	3525679403@qq.com	China	4334	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8140	58
cjbscvictory	13348960310 13348960310	3003867561@qq.com	China	10318	58

5,12-dihydroquinoxalino[2,3-b]quinoxaline
ML-090
Quinoxalino[2,3-b]quinoxaline, 5,11-dihydro-
5,12-Dihydroquinoxalino[2,3-b]quinoxaline (~90%)
6,11-dihydroquinoxalino[2,3-b]quinoxaline
NOX4,ML090,NADPH Oxidase,Inhibitor,NOX,HEK293 cell,NOX3,ML 090,NOX2,inhibit,ML-090,NOX1
Fluoflavine
531-46-4

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