GALANIN, PORCINE Chemische Eigenschaften,Einsatz,Produktion Methoden
Biologische Funktion
Galanin is
colocalized with acetylcholine, 5-HT , and NE in neurons or in brain regions implicated in cognitive and
affective behavior, suggesting a possible role in the regulation of 5-HT and NA neurotransmission in
depressive states and during the course of antidepressant therapy. Three galanin receptor subtypes have
been cloned and studied, but little is known about their specific contributions to behavioral processes. In the
CNS, galanin inhibits acetylcholine release, suggesting a possible role for galanin in cholinergic dysfunction;
inhibits neurotransmitter release and neuronal firing rate; and inhibits signal transduction by inhibition of
phosphatidyl inositol hydrolysis, leading to symptoms of depression. Thus, blocking the inhibitory effects of
galanin on monoamine neurotransmitters with galanin receptor antagonists would be predicted to mimic or
augment the action of the other monoamine classes of antidepressants."
Clinical Use
Since its discovery in 1983, the neuropeptide galanin has been found to be involved in a wide range of
functions, including pain sensation, sexual activity, feeding, and learning and memory. Galanin is widely
distributed in the central and peripheral nervous systems and in the endocrine system, and it acts as a
inhibitory neuromodulator of NE and 5-HT in the brain. The 29- to 30-amino-acid sequence of galanin is
conserved (almost 90% among species), indicating the importance of the molecule among species.
GALANIN, PORCINE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
