Enalaprilat
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- CAS-Nr.
- 76420-72-9
- Bezeichnung:
- Enalaprilat
- Englisch Name:
- Enalaprilat
- Synonyma:
- Enalapril acid;Vasotec IV;Enalaprilat;MK 421 diacid;Enalapril diacid;Enalaprilic Acid;ENALAPRILAT HYDRATE;Enalaprilat USP/EP/BP;enalaprilat (anhydrous);Enalapril maleate impurity C
- CBNumber:
- CB3163049
- Summenformel:
- C18H24N2O5
- Molgewicht:
- 348.39
- MOL-Datei:
- 76420-72-9.mol
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Enalaprilat Eigenschaften
- Schmelzpunkt:
- 148-151°C
- alpha
- D -67.0° (0.1M HCl)
- Siedepunkt:
- 601.0±55.0 °C(Predicted)
- Dichte
- 1.286±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- Very slightly soluble or slightly soluble in water, sparingly soluble in methanol, practically insoluble in acetonitrile.
- pka
- pKa 2.30 (Uncertain);3.39 (Uncertain)
- Aggregatzustand
- Solid
- Farbe
- White to off-white
- Wasserl?slichkeit
- Soluble in water with heating (~60°C)
- InChI
- 1S/C18H24N2O5/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25)/t12-,14-,15-/m0/s1
- InChIKey
- LZFZMUMEGBBDTC-QEJZJMRPSA-N
- SMILES
- O=C(N1CCC[C@H]1C(O)=O)[C@H](C)N[C@H](C(O)=O)CCC2=CC=CC=C2
- CAS Datenbank
- 76420-72-9(CAS DataBase Reference)
- EPA chemische Informationen
- L-Proline, N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl- (76420-72-9)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| WGK Germany |
2 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Enalaprilat Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Enalaprilat is the diacid active metabolite of enalapril. As an injectable ACE inhibitor, it
is reportedly useful in the treatment of uncomplicated accelerated hypertension and
hypertensive emergencies. Enalaprilat is more effective in reducing blood pressure in the
elderly than in the young, despite the fact that renin activity is lower in old age.
Chemische Eigenschaften
White Crystalline Solid
Verwenden
Enalapril is a ACE (angiotensin-converting enzyme) inhibitor, suggested to be more potent than Captopril (sc-200566). Studies indicate that Enalapril downregulates the expression of IL-β, IL-6, and NF-κB. Further studies show that Enalapril upregulates the expression of VEGF and heme oxygenase-1. Enalaprilat reports demonstrate that the compound has some antioxidant activity, which does not include the PKC-NADPH oxidase pathway.
Definition
ChEBI: Enalapril in which the ethyl ester group has been hydrolysed to the corresponding carboxylic acid. Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor and is used (often in the form of its prodrug, enalapril) in the treatment of hypertension an
heart failure, for reduction of proteinuria and renal disease in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is g
ven by intravenous injection, usually as the dihydrate.
Enalaprilat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Enalaprilat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 211)Lieferanten
76420-72-9(Enalaprilat)Verwandte Suche:
- ENALAPRILAT HYDRATE
- ENALAPRILAT USP(CRM STANDARD)
- L-Proline, 1-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]-, (S)-
- N-[1(S)-Carboxy-3-phenylpropyl]-L-alanyl-L-proline
- 1-[N-[(S)-1-Carboxy-3-phenylpropyl]-L-alanyl]-L-proline
- Enalapril diacid
- (2S)-1-[(2S)-2-{[(2R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]aMino}propanoyl]pyrrolidine-2-carboxylic acid
- Enalaprilat(Enalapril IMpurity C)
- N-[(1S)-1-Carboxy-3-phenylpropyl]-L-alanyl-L-proline
- L-Proline, N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-
- (S)-1-((S)-2-(((S)-1-Carboxy-3-phenylpropyl)amino)propanoyl)pyrrolidine-2-carboxylic acid
- enalaprilat (anhydrous)
- Enalaprilic Acid
- N-[(1S)-1-(Carboxy)-3-phenylpropyl]-L-alanyl]-L-proline Dihydrate
- Vasotec IV
- (2S)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenyl-propyl]amino]propanoyl]pyrrolidine-2-carboxylic acid
- Enalaprilat
- Enalaprilat (Enalapril EP Impurity C)
- Enalapril maleate impurity C
- (2S)-1-[(2S)-2-[[(1S)-1-Carboxy-3-p
- Enalaprilat USP/EP/BP
- Enalaprilat
DISCONTINUED. Please see E555375.
- Enalapril maleate EP Impurity C
- EnalaprilatQ: What is
Enalaprilat Q: What is the CAS Number of
Enalaprilat Q: What is the storage condition of
Enalaprilat Q: What are the applications of
Enalaprilat
- MK 421 diacid
- (2S)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]propanoyl]pyrrolidine-2-carboxylic Acid (Enalap
- (2S)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]propanoyl]pyrrolidine-2-carboxylic Acid (Enalaprilat)
- Enalapril acid
- 76420-72-9
- C18H28N2O7
- C18H24N2O52H2O
- C18H24N2O5
- Metabolite
- Intermediates & Fine Chemicals
- Metabolites & Impurities
- Pharmaceuticals
- Various Metabolites and Impurities
- Active Pharmaceutical Ingredients
