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L-744,832

L-744,832 Struktur
1177806-11-9
CAS-Nr.
1177806-11-9
Englisch Name:
L-744,832
Synonyma:
L-744832;L-744,832;L-744,832 Dihydrochloride;L-744,832 - CAS 1177806-11-9 - Calbiochem;(2S)-[(2S)-[(2R)-AMINO-3-MERCAPTO]-PROPYLAMINO-(3S)-METHYL]PENTYLOXY-3-PHENYLPROPIONYL-METHIONINE SULFONE ISOPROPYL ESTER BIS HYDRCHLORIDE;(2S)-[(2S)-[(2R)-Amino-3-mercapto]-propylamino-(3S)-methyl]pentyloxy-3-phenylpropionyl-methionine Sulfone Isopropyl Ester Bis Hydrchloride,
CBNumber:
CB3188792
Summenformel:
C26H47Cl2N3O6S2
Molgewicht:
632.7
MOL-Datei:
Mol file

L-744,832 Eigenschaften

Schmelzpunkt:
165-168°C
storage temp. 
-20°C Freezer
L?slichkeit
DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
White solid
Farbe
White
Wasserl?slichkeit
water: 15mg/mL
DMSO: 25mg/mL
InChIKey
PGOKBMWPBDRDGN-ZXGKGEBGSA-N

Sicherheit

WGK Germany  WGK 1
Speicherklasse 11 - Combustible Solids

L-744,832 Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

L-744,832 is White Cyrstalline Solid

Verwenden

L-744,832 is ras farnesyltransferase inhibitor. Induces tumor regression in transgenic mice with multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Induces p21 expressoin and arrests cells at G1. Causes enhanced mitotic

Allgemeine Beschreibung

A cell-permeable potent and selective thiol-containing peptidomimetic farnesyltransferase (FTase) inhibitor with anti-tumor properties. Rapidly blocks p70S6K activation and DNA synthesis and promotes apoptosis in transgenic mice. Induces p21 expression and cell cycle arrest in the G1 phase. Displays synergistic effect with paclitaxel and epothilones in inhibiting tumor growth. Also mimics many of the effects of Rapamycin (Cat. No. 553210) and may be effective against tumors that exhibit inappropriate activation of the mTOR/p70S6K pathway.

L-744,832 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


L-744,832 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 36)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Adachibio Inc.
+81-8027837258; +8108027837258
sales@adachibio.com Japan 938 58
Nextpeptide Inc
+86-0571-81612335 +8613336028439
sales@nextpeptide.com China 19908 58
Aladdin Scientific

tp@aladdinsci.com United States 52923 58
J & K SCIENTIFIC LTD. 18210857532; 18210857532
jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037
3bsc@sina.com China 15838 69
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32321 50
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51395 80
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
info@efebio.com China 9804 58
Alabiotech Inc. 001-619-354-5251
sales@alabiotech-e.com United States 972 60
Alpha Biopharmaceuticals Co., Ltd 0411-39042497
sales@alphabiopharm.com China 1951 58

1177806-11-9()Verwandte Suche:


  • (2S)-[(2S)-[(2R)-AMINO-3-MERCAPTO]-PROPYLAMINO-(3S)-METHYL]PENTYLOXY-3-PHENYLPROPIONYL-METHIONINE SULFONE ISOPROPYL ESTER BIS HYDRCHLORIDE
  • L-744832
  • (2S)-[(2S)-[(2R)-Amino-3-mercapto]-propylamino-(3S)-methyl]pentyloxy-3-phenylpropionyl-methionine Sulfone Isopropyl Ester Bis Hydrchloride,
  • L-744,832 Dihydrochloride
  • L-744,832
  • L-744,832 - CAS 1177806-11-9 - Calbiochem
  • 1177806-11-9
  • Inhibitors
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