Anti-Collapsin Response Mediator Protein 2, Anti-Dihydropyriminidase-like 2 (DPYSL2), Anti-TOAD-64, Anti-Dihydropyriminidase Related Protein-2 (DRP2, DRP-2, DHPRP2) Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anti-CRMP2 antibody produced in rabbit has been used in:
- western blotting
- immunohistofluorescence
- epifluorescence imaging
- coimmunoprecipitation
Allgemeine Beschreibung
Collapsin response mediator proteins CRMPs) consist of a family of cytosolic phosphoproteins expressed in the nervous system and involved in neuronal differentiation and axonal guidance.
Biochem/physiol Actions
CRMPs are a part of the collapsin/semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. CRMP2 is upregulated during development, and appears to be crucial for axon outgrowth. Glycogen synthase kinase 3 beta (GSK-3b) phosphorylates and inactivates CRMP-2 downstream of the phosphoinositide-3-kinase (PI3K/Akt) pathway, thus regulating neuronal polarity. CRMP2 interacts with tubulin dimers, kinesin-1 and WASP-family verprolin homologous protein 1 (WAVE1) complex to regulate axon outgrowth.
Anti-Collapsin Response Mediator Protein 2, Anti-Dihydropyriminidase-like 2 (DPYSL2), Anti-TOAD-64, Anti-Dihydropyriminidase Related Protein-2 (DRP2, DRP-2, DHPRP2) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
