N-(2-Aminophenyl)-N'-phenylheptanediamide
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- CAS-Nr.
- 537034-15-4
- Englisch Name:
- N-(2-Aminophenyl)-N'-phenylheptanediamide
- Synonyma:
- NKL 22;MDK-4154;HDACi-4b;NKL22, >98%;NKL 22, >98%;HDACi-4b (NKL22;HDAC inhibitor IV;NKL 22, 10 mM in DMSO;Histone Deacetylase Inhibitor IV;N-(2-Aminophenyl)-N'-phenylheptanediamide
- CBNumber:
- CB32486755
- Summenformel:
- C19H23N3O2
- Molgewicht:
- 325.4
- MOL-Datei:
- 537034-15-4.mol
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N-(2-Aminophenyl)-N'-phenylheptanediamide Eigenschaften
- Schmelzpunkt:
- 159-161°C
- Siedepunkt:
- 627.9±40.0 °C(Predicted)
- Dichte
- 1.212±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- L?slichkeit
- DMSO, Methanol
- Aggregatzustand
- Beige solid
- pka
- 14+-.0.70(Predicted)
- Farbe
- Off-White to Pale Beige
- InChI
- 1S/C19H23N3O2/c20-16-11-7-8-12-17(16)22-19(24)14-6-2-5-13-18(23)21-15-9-3-1-4-10-15/h1,3-4,7-12H,2,5-6,13-14,20H2,(H,21,23)(H,22,24)
- InChIKey
- ZAIULUYKQLVQFH-UHFFFAOYSA-N
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 2 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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N-(2-Aminophenyl)-N'-phenylheptanediamide Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Off-White Solid
Verwenden
Histone deacetylase inhibitor IV. A cell-permeable pimeloylanilide compound that acts as a FXN-(frataxin gene) specific HDAC inhibitor. Reverses the silencing of FXN transcription in FRDA (Friedrich’s ataxia) cells due to hypoacetylation of histones H3 and H4.
Allgemeine Beschreibung
A cell-permeable pimeloylanilide compound that acts as a
FXN- (frataxin gene) specific HDAC (histone deacetylase) inhibitor. Reverses the silencing of
FXN transcription in FRDA (Friedreich′s ataxia) cells (~3-fold increase of
FXN mRNA at 5 μM in primary FRDA lymphocytes and ~3-fold frataxin expression in FRDA cell line at 2.5 μM) due to hypoacetylation of histones H3 and H4 by increasing acetylation at H3K14, H4K5 and H4K12, without significant changes in acetylation at H3K9, H4K8 and H4K16. In comparison, Trichostatin-A (Cat. No.
647925 and
647926) and SAHA, two other commonly used HDAC inhibitors, exhibit no effect on
FXN transcription.
N-(2-Aminophenyl)-N'-phenylheptanediamide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
N-(2-Aminophenyl)-N'-phenylheptanediamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 90)Lieferanten
- N1-(2-AMinophenyl)-N7-phenylheptanediaMide
- NKL 22
- HDAC inhibitor IV
- Histone Deacetylase Inhibitor IV
- N-(2-Aminophenyl)-N'-phenylheptanediamide
- Heptanediamide, N1-(2-aminophenyl)-N7-phenyl-
- Histone Deacetylase Inhibitor IV - CAS 537034-15-4 - Calbiochem
- MDK-4154
- NKL22, >98%
- NKL 22, >98%
- HISTONE DEACETYLASE INHIBITOR IV;NKL22;NKL-22;NKL 22
- HDACi-4b
- Huntington's,abnormalities,histone,NKL 22,Histone deacetylases,transcriptional,HDAC,NKL-22,Inhibitor,deacetylases,phenotype,inhibit,NKL22
- N-(2-Aminophenyl)-N’-phenylheptanediamide
- NKL 22, 10 mM in DMSO
- HDACi-4b (NKL22
- 537034-15-4
- Amines
- Aromatics
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
