Tubacin
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- CAS-Nr.
- 537049-40-4
- Englisch Name:
- Tubacin
- Synonyma:
- Tubacin;BML-GR362;4R,6S)N8-[(2R,dioxan-Tubacin, >=98%;diphenyl-oxazolyl)
- CBNumber:
- CB32519138
- Summenformel:
- C41H43N3O7S
- Molgewicht:
- 721.86
- MOL-Datei:
- 537049-40-4.mol
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Tubacin Eigenschaften
- Schmelzpunkt:
- 155 - 157°C
- storage temp.
- -20°C
- L?slichkeit
- DMSO: ≥10mg/mL
- Aggregatzustand
- powder
- Farbe
- white to tan
- InChIKey
- BHUZLJOUHMBZQY-UHHSDZQINA-N
- SMILES
- C(NC1=CC=C([C@H]2O[C@@H](CSC3=NC(C4=CC=CC=C4)=C(C4=CC=CC=C4)O3)C[C@@H](C3=CC=C(CO)C=C3)O2)C=C1)(=O)CCCCCCC(NO)=O |&1:6,8,29,r|
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Tubacin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Tubacin: an HDAC6 Selective Inhibitor.
Tubacin (tubulin acetylation inducer) is a highly potent and selective, reversible, cell-permeable inhibitor of HDAC6 (IC50=0.004μM). It dose-dependently boosted the release of influenza A virus (IAV) progeny through the increase of acetylated microtubules to effectively move viral components to the plasma membrane. It could reduce the Replication of the Japanese Encephalitis Virus via the Decrease of Viral RNA Synthesis. Tubacin was demonstrated as a host-targeting agent with preventive and therapeutic activities against the Japanese encephalitis virus. Concentration in cell culture experiments typically ranges from 2-50μM[1].
Verwenden
Tubacin is tubulin acetylation inducer that selectively inhibits histone deacetylase (HDAC6).
Biochem/physiol Actions
Tubacin triggers the release of reactive oxygen species and mediates caspase-3-independent apoptosis of Epstein-Barr virus (EBV)-positive Burkitt lymphoma cells. It suppresses the proliferation of acute lymphoblastic leukemia (ALL) cells and enhances the effect of chemotherapy to treat ALL cells. Tubacin prevents the epileptic activity and neuronal migration defects caused due to lowered expression of Srpx2 in rats.
Tubacin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Tubacin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 127)Lieferanten
- Tubacin
- N1-(4-((2R,4R,6S)-4-((4,5-diphenyloxazol-2-ylthio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-dioxan-2-yl)phenyl)-N8-hydroxyoctanediamide
- N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy-octanediamide Tubacin
- N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy-octanediamide
- Tubacin, >=98%
- N1-(4-((2R,4R,6S)-4-(((4,5-Diphenyloxazol-2-yl)thio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-di
- BML-GR362
- Tubacin (BML-GR362)
- Octanediamide, N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy-, rel-
- Octanediamide,N-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxy-, rel-
- Tubacin (tubulin acetylation inducer)
- rel-N1-(4-((2R,4R,6S)-4-(((4,5-Diphenyloxazol-2-yl)thio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-dioxan-2-yl)phenyl)-N8-hydroxyoctanediamide
- Tubacin,Inhibitor,HDAC,Virus Protease,inhibit,Histone deacetylases
- (hydroxymethyl)
- [(2R,
- 4R,
- 6S)
- dioxan-
- diphenyl-
- N8-
- Octanediamide, N1-
- oxazolyl)
- Tubacin, 10 mM in DMSO
- N-[4-[(2R,4R,6S)-4-[(4,5-diphenyl-1,3-oxazol-2-yl)sulfanylmethyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide
- CAS:537049-40-4
- 537049-40-4
- C41H43N3O7S
- Inhibitors
