Belinostat (PXD101)
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- CAS-Nr.
- 414864-00-9
- Englisch Name:
- Belinostat (PXD101)
- Synonyma:
- Belinostat;PXD101;CS-424;PX105684;NSC726630;belinosta;BelioMstat;BENLINOSTAT;Belinostat-D5;Rac-Belinostat
- CBNumber:
- CB3260643
- Summenformel:
- C15H14N2O4S
- Molgewicht:
- 318.35
- MOL-Datei:
- 414864-00-9.mol
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Belinostat (PXD101) Eigenschaften
- Schmelzpunkt:
- 142 - 145°C
- Dichte
- 1.427±0.06 g/cm3(Predicted)
- storage temp.
- Amber Vial, Refrigerator, Under inert atmosphere
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 8.31±0.10(Predicted)
- Farbe
- Off-White to Pale Orange
- Stabilit?t:
- Light Sensitive
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301 |
BEI VERSCHLUCKEN |
| P304 |
BEI EINATMEN |
| P305 |
+ P351 + P338BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Vorhandene Kontaktlinsen nach M?glichkeit entfernen. |
| P330 |
Mund ausspülen. |
| P338 |
Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter ausspülen |
| P340 |
Die betroffene Person an die frische Luft bringen und in einer Position ruhigstellen, die das Atmen
erleichtert. |
| P351 |
Einige Minuten lang behutsam mit Wasser ausspülen. |
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Belinostat (PXD101) Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Belinostat is a drug which was developed by Spectrum Pharmaceuticals
and is currently marketed by Onxeo as Beleodaq®. The
drug, which received fast track designation by the United States
Food and Drug Administration (US FDA) and was approved for
the treatment of hematological malignancies and solid tumors
associated with peripheral T-cell lymphoma (PTCL) in 2014, is a
histone deacetylase (HDAC) inhibitor and is the third such treatment
to receive accelerated approval for PTCL, the others being
vorinostat (Zolinza®) and pralatrexate (Folotyn®). Although belinostat
was not yet approved in Europe as of August 2014, the
compound exhibits a safety profile considered to be acceptable
for HDAC inhibitors–less than 25% of patients reported adverse
effects and these most frequently were nausea, fatigue, pyrexia,
anemia, and emesis.
Verwenden
Belinostat is a novel histone deacetylase 3 selective inhibitor, which protects the β cells from cytokine-induced apoptosis.
Definition
ChEBI: A hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity.
Belinostat (PXD101) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Belinostat (PXD101) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 231)Lieferanten
- PXD101, Beliomsta
- BELINOSTAT (PXD101);PXD101
- N-HYDROXY-3-[3-[(PHENYLAMINO)SULFONYL]PHENYL]-2-PROPENAMIDE
- N-HYDROXY-3-(3-PHENYLSULFAMOYLPHENYL)ACRYLAMIDE
- Belinostat(PXD101)
- 2-PropenaMide, N-hydroxy-3-[3-[(phenylaMino)sulfonyl]phenyl]-
- PX105684
- Belinostat-13C6
- Belinostat-D5
- (E)-N-hydroxy-3-(3-(N-phenylsulfaMoyl)phenyl)acrylaMide
- PXD101, BelioMstat
- BelioMstat
- BENLINOSTAT
- BelioMstat
PXD101
- NSC726630
- N-Hydroxy-3-(3-phenylsulfamoylphenyl)acrylamide Belinostat
- Belinostat, >=98%
- Belinostat, 98%, a new type of HDAC inhibitor
- N-Hydroxy-3-(3-(N-phenylsulfamoyl)phenyl)acrylamide
- PXD101;PX105684;PXD-101;PXD 101;PX-105684;NSC726630
- Belinostat (PXD101), >98%
- (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide
- CS-424
- (E/Z)-Belinostat
- Belinostat (PXD101) USP/EP/BP
- Belinostat(Random Configuration)
- belinosta
- NSC726630|||PXD101|||PX-105684
- Rac-Belinostat
- Rac-Belinostat, 10 mM in DMSO
- BELINOSTAT DRUG SUBSTANCE
- Belinostat
- PXD101
- 414864-00-9
- C15H9N2O4SD5
- Inhibitors
- API
- Inhibitor
