IOX2
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- CAS-Nr.
- 931398-72-0
- Englisch Name:
- IOX2
- Synonyma:
- IOX2;JICL38;CS-564;IOX2 ，S2919;IOX 2, >=98%;IOX2(Glycine);IOX-2; IOX2; IOX 2;DesidustatImpurity1;IOX2, 10 mM in DMSO;IOX2;IOX 2;IOX-2;JICL38
- CBNumber:
- CB32638323
- Summenformel:
- C19H16N2O5
- Molgewicht:
- 352.34
- MOL-Datei:
- 931398-72-0.mol
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IOX2 Eigenschaften
- Siedepunkt:
- 642.8±55.0 °C(Predicted)
- Dichte
- 1.470±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: soluble5mg/mL, clear (warmed)
- pka
- 3.61±0.10(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
- InChI
- 1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23)
- InChIKey
- CAOSCCRYLYQBES-UHFFFAOYSA-N
- SMILES
- OC(C1=C(N2CC3=CC=CC=C3)C=CC=C1)=C(C(NCC(O)=O)=O)C2=O
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
T |
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| R-S?tze: |
25 |
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| S-S?tze: |
45 |
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| RIDADR |
UN 2811 6.1 / PGIII |
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| WGK Germany |
3 |
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| Speicherklasse |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications |
Acute Tox. 3 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
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P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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IOX2 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM.
Biochem/physiol Actions
IOX2 is selective and potent inhibitor of prolyl hydroxylases (PHD). Stabilization of HIF-1R through inhibition of PHD has been examined as a potential treatment for ischemic diseases including anemia, myocardial infarction, and stroke. IOX2 is a selective inhibitor of the hypoxia inducible factor (HIF) prolyl-hydroxylases (PHD) that exhibits up-regulation of HIF1a in zebrafish. For full characterization details, please visit the IOX2 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
IOX2 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
IOX2 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 152)Lieferanten
- Glycine, N-[[1,2-dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]-
- N-[[4-Hydroxy-2-oxo-1-(phenylmethyl)-1,2-dihydro-3-quinolinyl]carbonyl]glycine IOX2
- JICL38
- N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]-glycine
- (1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)glycine
- IOX 2, >=98%
- IOX2;IOX 2;IOX-2;JICL38
- IOX2
- 2-(1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxaMido)acetic acid
- 2-[(1-BENZYL-4-HYDROXY-2-OXOQUINOLINE-3-CARBONYL)AMINO]ACETIC ACID
- N-[[4-Hydroxy-2-oxo-1-(phenylmethyl)-1,2-dihydro-3-quinolinyl]carbonyl]glycine
- IOX2(Glycine)
- IOX-2; IOX2; IOX 2
- CS-564
- DesidustatImpurity1
- HIF-PH,Inhibitor,inhibit,HIF/HIF Prolyl-Hydroxylase,IOX-2,IOX2,HIFs,Hypoxia-inducible factors
- IOX2, HIF-1alpha prolyl hydroxylase-2 (PHD2) inhibitor
- IOX2, 10 mM in DMSO
- N-[(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydro-3-Quinolinyl)carbonyl]glycin
- IOX2 ，S2919
- 931398-72-0
- Inhibitors
- Inhibitor
