1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-
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- CAS-Nr.
- 509102-00-5
- Englisch Name:
- 1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-
- Synonyma:
- MIM1;CS-1192;MIM 1;MIM-1;Inhibitor of Mcl-1;MIM1, 10 mM in DMSO;1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-;4-[[[2-(Cyclohexylimino)-4-methyl-3(2H)-thiazolyl]imino]methyl]-1,2,3-benzenetriol;inhibit,Bcl-2 Family,Inhibitor of Mcl1,Inhibitor,MIM-1,MIM1,MIM 1,Inhibitor of Mcl 1;1,2,3-Benzenetriol, 4-[[[2-(cyclohexylimino)-4-methyl-3(2H)-thiazolyl]imino]methyl]-
- CBNumber:
- CB32652150
- Summenformel:
- C17H21N3O3S
- Molgewicht:
- 347.43
- MOL-Datei:
- 509102-00-5.mol
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1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4- Eigenschaften
- Siedepunkt:
- 559.6±60.0 °C(Predicted)
- Dichte
- 1.40±0.1 g/cm3(Predicted)
- L?slichkeit
- insoluble in EtOH; insoluble in H2O; ≥12.15 mg/mL in DMSO
- Aggregatzustand
- A crystalline solid
- pka
- 7.73±0.45(Predicted)
- Farbe
- White to off-white
Sicherheit
1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4- Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
MIM1 is an inhibitor of Mcl-1, an antiapoptotic Bcl-2 family protein with a role in cancer. It selectively engages the canonical groove of Mcl-1, inhibiting its ability to bind BH3 domains (IC
50 = 4.7 μM). MIM1 induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells.
Verwenden
MIM1 binds to MCL-1 and aids in the modulation of cell death, division and differentiation. MIM1 may be used for treating hyperproliferative disorders, angiogenesis disorders, cell cycle regulation disorders, autophagy regulation disorders, inflammatory disorders, and/or infectious disorders.
1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4- Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4- Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 68)Lieferanten
509102-00-5()Verwandte Suche:
- MIM1
- 4-[[[2-(Cyclohexylimino)-4-methyl-3(2H)-thiazolyl]imino]methyl]-1,2,3-benzenetriol
- 1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-
- MIM 1;MIM-1
- CS-1192
- Inhibitor of Mcl-1
- 1,2,3-Benzenetriol, 4-[[[2-(cyclohexylimino)-4-methyl-3(2H)-thiazolyl]imino]methyl]-
- inhibit,Bcl-2 Family,Inhibitor of Mcl1,Inhibitor,MIM-1,MIM1,MIM 1,Inhibitor of Mcl 1
- MIM1, 10 mM in DMSO
- 509102-00-5
