Ribociclib
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- CAS-Nr.
- 1211441-98-3
- Englisch Name:
- Ribociclib
- Synonyma:
- 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;LEE11;LEE01;CS-1001;Kisqali.;Ribociclib;LEE011, >=98%;Ribociclib-d8;Ribociclib base
- CBNumber:
- CB32677045
- Summenformel:
- C23H30N8O
- Molgewicht:
- 434.54
- MOL-Datei:
- 1211441-98-3.mol
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Ribociclib Eigenschaften
- Siedepunkt:
- 730.8±70.0 °C(Predicted)
- Dichte
- 1.39±0.1 g/cm3(Predicted)
- Dampfdruck
- 0-0Pa at 20-25℃
- storage temp.
- -20°C
- L?slichkeit
- Soluble in DMSO (up to 10 mg/ml)
- pka
- 8.67±0.10(Predicted)
- Aggregatzustand
- solid
- Farbe
- Off-white
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
- InChIKey
- RHXHGRAEPCAFML-UHFFFAOYSA-N
- SMILES
- C1(NC2=NC=C(N3CCNCC3)C=C2)=NC=C2C=C(C(N(C)C)=O)N(C3CCCC3)C2=N1
- LogP
- -0.8-2.3 at 20℃ and pH4-11
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Ribociclib Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
LEE011 is a cyclin-
dependent kinase (CDK) inhibitor that targets cyclin D1/CDK4 and cyclin D3/CDK6 at nanomolar concentrations. It inhibits retinoblastoma protein phosphorylation, which prevents CDK-mediated G
1-S phase transition, arresting the cell cycle in the G
1 phase, suppressing DNA synthesis, and inhibiting cancer cell growth. LEE011 has been shown to reduce proliferation in 12 of 17 human neuroblastoma-
derived cell lines by inducing cytostasis (mean IC
50 = 306 nM in sensitive lines).
Charakteristisch
Class: serine/threonine protein kinase
Treatment: Breast cancer
Oral bioavailability = 66%
Elimination half-life = 32 h
Protein binding = 70%
Verwenden
LEE 011 can be used in biological study of kinome-wide RNA interference screen reveals a role for PDK1 in acquired resistance to CDK4/6 inhibition in ER-positive breast cancer.
Mechanism of action
Ribociclib is a dual cdk4/cdk6 inhibitor. Induces G1 phase cell cycle arrest and senescence in neuroblastoma cell lines (IC50 = 306 nM). Delays tumor growth in vivo.
Ribociclib Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Ribociclib Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 269)Lieferanten
1211441-98-3()Verwandte Suche:
- 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide LEE 011
- LEE 011 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
- LEE011, >=98%
- 7-CYCLOPENTYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE
- LEE-011, Ribociclib
- 7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide, 7-cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-
- Ribociclib 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
- 7-Cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidi
- Ribociclib
- Ribociclib USP/EP/BP
- Ribociclib Lee011 Powder
- LEE11
- 7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide
- 7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide, 7-cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyri
- LEE01
- CS-1001
- LEE 011; LEE-011;RIBOCICLIB;LEE011
- Ribociclib-d8
- LEE-011,Ribociclib,LEE011
- Kisqali.
- LEE-011. LEE 011
- LEE011; LEE-011. LEE 011; RIBOCICLIB; KISQALI.
- Cyclin dependent kinase,LEE 011,Ribociclib,inhibit,Inhibitor,LEE-011,CDK
- Ribociclib base
- Ribociclib, 10 mM in DMSO
- 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
- 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
- Ribociclib Powder
- Ribociclib pure powder
- 1211441-98-3
- C23H30N8O
- Inhibitors
