EveroliMus-d4
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- CAS-Nr.
- 1338452-54-2
- Englisch Name:
- EveroliMus-d4
- Synonyma:
- D4-Everolimus;Everolimus-d4;EveroliMus-d4 (~90%);Everolimus-d4 (>85%);Everolimus-D4 (Standard);Everolimus-D4 solution;Everolimus (2-hydroxyethyl-D?, 98%);EVEROLIMUS (2-HYDROXYETHYL-D4, 98%);Everolimus-d4 (Everolimus Impurity);Everolimus Impurity 24(Everolimus-d4)
- CBNumber:
- CB32714520
- Summenformel:
- C53H79D4NO14
- Molgewicht:
- 962.249067112
- MOL-Datei:
- 1338452-54-2.mol
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EveroliMus-d4 Eigenschaften
- storage temp.
- Store at 4°C
- L?slichkeit
- Chloroform: Soluble,Methanol: Soluble
- Aggregatzustand
- A solid
- Farbe
- White to off-white
- Stabilit?t:
- Hygroscopic
- Major Application
- clinical testing
- InChIKey
- HKVAMNSJSFKALM-ULVVDLMCSA-N
- SMILES
- [2H]C([2H])(O)C([2H])([2H])OC1CCC(CC(C)C2CC(=O)C(C)\C=C(C)\C(O)C(OC)C(=O)C(C)CC(C)\C=C\C=C\C=C(C)\C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC)CC1OC
- CAS Number Unlabeled
- 159351-69-6
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 2 |
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| Speicherklasse |
3 - Flammable liquids |
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| Hazard Classifications |
Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Flam. Liq. 2 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H372 |
Sch?digt bei Hautkontakt und Verschlucken die Organe bei l?ngerer oder wiederholter Exposition. |
Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) |
Kategorie 1 |
Achtung |
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P260, P264, P270, P314, P501 |
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| Sicherheit |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P314 |
Bei Unwohlsein ?rztlichen Rat einholen / ?rztliche Hilfe hinzuziehen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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EveroliMus-d4 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Everolimus-d
4 is intended for use as an internal standard for the quantification of everolimus by GC- or LC-MS. Everolimus is a hydroxyethyl ether form of rapamycin that inhibits mTOR signaling through both mTORC1 and mTORC2 when added to cells at 20 nM. It is orally available and shows improved pharmacokinetics and pharmacodynamics over rapamycin. Through its inhibition of mTOR, everolimus inhibits cell proliferation, metabolism, and angiogenesis in certain types of cancer. It also acts as an immunosuppressive agent in the context of organ transplantation.
Allgemeine Beschreibung
A stable-labeled internal standard for the immunosuppressant Everolimus, marketed as Zortress
and Certican for use in organ transplantation and Afinitor
for treatment of kidney and pancreatic cancers. Clinical laboratories quantitate everolimus levels in patient whole blood samples using LC-MS/MS. While many everolimus LC-MS/MS methods use 32-desmethoxyrapamycin or ascomycin as an internal standard, higher levels of variability / lower levels of reproducibility may occur in the analysis along with the potential for interferences. Use of a stable-labeled analog of everolimus is the best choice to minimize variability or mitigate any potential interference in LC-MS/MS analysis.
EveroliMus-d4 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
EveroliMus-d4 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 55)Lieferanten
- EveroliMus-d4 (~90%)
- Everolimus-d4
- Everolimus D4Q: What is
Everolimus D4 Q: What is the CAS Number of
Everolimus D4 Q: What is the storage condition of
Everolimus D4 Q: What are the applications of
Everolimus D4
- EVEROLIMUS (2-HYDROXYETHYL-D4, 98%)
- Everolimus Impurity 24(Everolimus-d4)
- Everolimus-d4 (Everolimus Impurity)
- Everolimus-D4 solution
- Everolimus-d4 (>85%)
- D4-Everolimus
- Everolimus (2-hydroxyethyl-D?, 98%)
- Everolimus-D4 (Standard)
- 1338452-54-2
