1-(tert-Butyl)hydrogen-(S)-pyrrolidin-1,2-dicarboxylat
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- CAS-Nr.
- 15761-39-4
- Bezeichnung:
- 1-(tert-Butyl)hydrogen-(S)-pyrrolidin-1,2-dicarboxylat
- Englisch Name:
- BOC-L-Proline
- Synonyma:
- BOC-PRO-OH;(tert-butoxycarbonyl)-L-proline;BOC-PRO;N-BOC-L-PROLINE;(tert-butoxycarbonyl)proline;BOC-L-PRO;BOC-L-PRO-OH;N-BOC-PROLINE;N-(TERT-BUTOXYCARBONYL)-L-PROLINE;(2S)-1-tert-butoxycarbonylpyrrolidine-2-carboxylic acid
- CBNumber:
- CB3274189
- Summenformel:
- C10H17NO4
- Molgewicht:
- 215.25
- MOL-Datei:
- 15761-39-4.mol
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1-(tert-Butyl)hydrogen-(S)-pyrrolidin-1,2-dicarboxylat Eigenschaften
- Schmelzpunkt:
- 133-135 °C(lit.)
- alpha
- -60.5 º (c=1, HAc)
- Siedepunkt:
- 355.52°C (rough estimate)
- Dichte
- 1.1835 (rough estimate)
- Brechungsindex
- -60 ° (C=2, AcOH)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- L?slichkeit
- Soluble in acetic acid.
- pka
- 4.01±0.20(Predicted)
- Aggregatzustand
- Crystals or Crystalline Powder
- Farbe
- White
- Optische Rotation
- [α]20/D 61±2°, c = 2% in acetic acid
- BRN
- 15828
- Major Application
- peptide synthesis
- InChI
- 1S/C10H17NO4/c1-10(2,3)15-9(14)11-6-4-5-7(11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)/t7-/m0/s1
- InChIKey
- ZQEBQGAAWMOMAI-ZETCQYMHSA-N
- SMILES
- CC(C)(C)OC(=O)N1CCC[C@H]1C(O)=O
- CAS Datenbank
- 15761-39-4(CAS DataBase Reference)
- EPA chemische Informationen
- 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- (15761-39-4)
1-(tert-Butyl)hydrogen-(S)-pyrrolidin-1,2-dicarboxylat Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
N-Boc-L-proline is a synthetic intermediate. It has been used in the synthesis of enantioselective catalysts for aldol reactions and hepatitis C virus (HCV) NS5A inhibitors.
Chemische Eigenschaften
White to off-white microcrystalline powder
Verwenden
N-Boc-L-proline is used as an intermediate in organic synthesis. It is also used to prepare daclatasvir, which inhibits the hepatitis C virus (HCV) non-structural 5A (NS5A) protein. Further, it is used as a drug in the treatment of hepatitis C virus (HCV).
synthetische
Triethylamine (16.5 mL, 0.12 mmol) was added dropwise over a period of 10 min to a stirred, ice-cold suspension of l-proline (10.0 g, 8.7 mmol) in dichloromethane (200 mL) in a 500-mL three-necked, round-bottomed flask. A solution of Boc2O (28.3 g, 0.13 mmol) in dichloromethane (100 mL) was then added over a period of 10 min and the mixture was stirred for 2.5 h. Thereafter, 10% aqueous citric acid (50 mL) was added, and the dichloromethane layer was washed with saturated brine (2×50 mL) and with water (50 mL). After drying the organic phase over magnesium sulfate, the solvent was evaporated and the residue was taken up in hot ethyl acetate. Dilution of this solution with hexane gave the product, N-tertbutoxycarbonyl- L-proline (17.8 g, 95%); mp 138–140℃; TLC (silica gel): Rf=0:36 (EtOAc/MeOH, 1:1).
1-(tert-Butyl)hydrogen-(S)-pyrrolidin-1,2-dicarboxylat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1-(tert-Butyl)hydrogen-(S)-pyrrolidin-1,2-dicarboxylat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 731)Lieferanten
15761-39-4(1-(tert-Butyl)hydrogen-(S)-pyrrolidin-1,2-dicarboxylat)Verwandte Suche:
- BOC-L-PROLINE-OH
- L-Proline, N-BOC protected, (2S)-1-(tert-Butoxycarbonyl)pyrrolidine-2-carboxylic acid
- L-PROLINE-N-T-BOC
- BOC-L-Proline, 99+% 25GR
- (S)-1-(tert-buto×ycarbonyl)pyrrolidine-2-carbo×ylic acid
N-Boc-L-Proline
- N-Boc-L-proline
Boc-Pro-OH
- N-(tert-Butoxycarbonyl)-L-proline
- N-(tert-Butoxycarbonyl)-L-proline
- (S)-Pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester
- The BOC-L- pro
- N-(tert-Butoxycarbonyl)-L-proline, 99.0%(T)
- Boc-L-Proline SynonyMs N-(tert-Butoxycarbonyl)-L-proline
- Boc-Pro-OH >=99.0% (T)
- Daclatasvir Intermediates 3
- 1-tert-Butyloxycarbonyl-L-proline
- (S)-Boc-pyrrolidine-2-carboxylic acid
- Boc-L-proline≥ 98% (HPLC)
- TBOC-L-PROLINE
- T-BUTYLOXYCARBONYL-L-PROLINE
- RARECHEM AL BO 1463
- 1,2-PYRROLIDINEDICARBOXYLIC ACID, 1-(1,1-DIMETHYLETHYL) ESTER, (2S)-
- 1-(tert-butyl) hydrogen (S)-pyrrolidine-1,2-dicarboxylate
- BOC-L-Proline, 99+%
- Boc-DL-Proline-OH
- TERT-BUTYLOXYCARBONYLPROLINE
- N-ALPHA-T-BUTYLOXYCARBONYL-L-PROLINE
- Boc-Pro-OH (Boc-L-Proline
- N-(tert-Butoxycarbonyl)-L-proline, Boc-L-proline
- (2S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
- Butoxycarbonylproilne
- N-(tert-Butoxycarbonyl)-L-proline ,98.5%
- (2S)-1-(tert-Butyloxycarbonyl)pyrrolidine-2α-carboxylic acid
- (2S)-1,2-Pyrrolidinedicarbonic acid 1-tert-butyl ester
- Boc-Pro-OH (Boc-L-Proline: N-(tert-Butoxycarbonyl)-L-proline)
- (2S)-Pyrrolidine-2-carboxylic acid, N-BOC protected
- (S)-1,2-Pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) ester
- N-(TERT-BUTOXYCARBONYL)-L-PROILNE
- N-(TERT-BUTYLOXYCARBONYL)-L-PROLINE
- N-T-BUTOXYCARBONYL-L-PROLINE
- N-T-BOC-L-PROLINE
- n-alpha-tert-boc-l-proline
- N-ALPHA-TERT-BUTYLOXYCARBONYL-L-PROLINE
- N-ALPHA-T-BUTOXYCARBONYL-L-PYRROLIDINE-2-CARBOXYLIC ACID
- N-ALPHA-T-BUTOXYCARBONYL-L-PROLINE
- N-ALPHA-T-BOC-L-PROLINE
- BOC-L-PROLINE extrapure
- 1-Tert-Butoxycarbonyl-L-proline
- Boc-L-proline ,98.5%
- BOC-PYRD(2)-OH
- BOC-L-PROLINE
- 1-(1,1-dimethylethyl)ester,(s)-2-pyrrolidinedicarboxylicacid
- (Tert-Butoxy)Carbonyl Pro-OH
- N-(tert-Butoxycarbonyl)-L-proline>
- BOC-L-Proline USP/EP/BP
- N-(tert-butoxycarbonyl)-laevo-proline
- BOC-PROLINE
- Pentanoicacid,2,9-dioxo-,methylester
- N-tert-Boc-L-Proline
