Toremifene citrate
|
|
|
- CAS-Nr.
- 89778-27-8
- Englisch Name:
- Toremifene citrate
- Synonyma:
- fareston;nk622;fc1157a;Ccris 6719;Nsc 613680;Toremifine;Toremifene citrat;Oremifene Citrate;TOREMIFENE CITRATE;Toremefene Citrate
- CBNumber:
- CB3287855
- Summenformel:
- C26H28ClNO.C6H8O7
- Molgewicht:
- 598.08
- MOL-Datei:
- 89778-27-8.mol
|
Toremifene citrate Eigenschaften
- Schmelzpunkt:
- 160-162°C
- Siedepunkt:
- 146-148C
- Dichte
- 1,045g/cm
- Brechungsindex
- 1,416-1,418
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: >10mg/mL
- Aggregatzustand
- powder
- Farbe
- white to off-white
- Merck
- 14,9550
- Stabilit?t:
- Light Sensitive
- InChIKey
- IWEQQRMGNVVKQW-OQKDUQJOSA-N
- SMILES
- OC(=O)CC(O)(CC(O)=O)C(O)=O.CN(C)CCOc1ccc(cc1)C(=C(\CCCl)c2ccccc2)\c3ccccc3
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi,N,Xn |
|
|
| R-S?tze: |
36/37/38-50/53-41-22 |
|
|
| S-S?tze: |
26-37/39-61-60-39 |
|
|
| RIDADR |
UN 3077 9 / PGIII |
|
|
| WGK Germany |
3 |
|
|
| RTECS-Nr. |
KH2156700 |
|
|
| Speicherklasse |
11 - Combustible Solids |
|
|
| Hazard Classifications |
Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1
Eye Dam. 1 |
|
|
| Bildanzeige (GHS) |
  
|
| Alarmwort |
Achtung
|
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
|
P264, P270, P301+P312, P330, P501 |
| H318 |
Verursacht schwere Augensch?den. |
Schwere Augensch?digung |
Kategorie 1 |
Achtung |
|
P280, P305+P351+P338, P310 |
| H410 |
Sehr giftig für Wasserorganismen mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 1 |
Warnung |
|
P273, P391, P501 |
|
| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
|
Toremifene citrate Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
Toremifene (citrate) is an orally bioavailable selective estrogen receptor modulator (SERM) that evokes tissue-dependent effects similar to that of tamoxifen . It has been shown to block estrogen-stimulated growth of MCF-7 breast cancer cells grown in tissue culture, to inhibit ovariectomy-induced bone loss in rats, and to stimulate endometrial growth similar to that of tamoxifen.
Chemische Eigenschaften
White-to-Off-White Solid
Verwenden
Toremifene citrate salt has been used:
- in cell-based ELISA
- as a positive control to detect its antiviral activity against Ebola virus (EBOV)
- to treat MCF7 and T47D breast cancer cell lines
Allgemeine Beschreibung
Toremifene, 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine(Fareston), differs structurally fromtamoxifen only by having a chloroethyl group (rather than anethyl group) attached to the triphenylethylene structure. Asmight be expected, the pharmacological actions of toremifeneand tamoxifen are quite similar. Toremifene is also a SERM,with estrogen antagonist action in breast tissue but agonist actionin the endometrium, on bone tissue, and on serum lipidprofiles. Recent clinical data indicate that the incidence ofendometrial cancer is lower with toremifene use than with tamoxifen. Toremifene is used in the treatment of metastaticbreast cancer in postmenopausal women.
Toremifene citrate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Toremifene citrate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 279)Lieferanten
89778-27-8()Verwandte Suche:
- (z)-4-chloro-1,2-diphenyl-1-(4-(2-(n,n-dimethylamino)ethoxy)phenyl)-1-butene
- 2-(4-(4-chloro-1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethyl-ethanamin(z)-ethanamin
- 2-hydroxy-1,2,3-propanetricarboxylate(1:1)
- fc1157a
- nk622
- TOREMIFENE CITRATE
- (z)-2-[4-(4-chloro-1,2-diphenyl-1-butenyl)phenoxy]-n,n-dimethyl-ethanamine 2-hydroxy-1,2,3-propanetricarboxylate
- TROPISETRON CITRATE
- (Z)-4-Chloro-1,2-diphenyl-1-(4-(2-(N,N-dimethylamino)ethoxy)phenyl)-1-butene citrate (1:1)
- Ccris 6719
- Ethanamine, 2-(4-(4-chloro-1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
- Nsc 613680
- Toremefene Citrate
- 2-[4-[(1Z)-4-CHLORO-1,2-DIPHENYL-1-BUTENYL]PHENOXY]-N,N-DIMETHYLETHANAMINE
- Toremifine
- ToreMifene Citrate(Fareston, Acapodene)
- 2-[4-[(1Z)-4-Chloro-1,2-diphenyl-1-butenyl]phenoxy]-N,N-diMethylethanaMine 2-Hydroxy-1,2,3-propanetricarboxylate
- (Z)-4-Chloro-1-(4-dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene Citrate
(Z)-2-[4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine Citrate
- ToreMifene (Z-isoMer)-d6
- TOREMIPHENE CITRATE
- 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-ethanamine, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
- Toremifene citrate (Z)-2-[4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-ethanamine 2-hydroxy-1,2,3-propanetricarboxylate
- Toremifene citrate salt
- (Z)-2-[4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine Citrate
- (Z)-4-Chloro-1-(4-dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene Citrate
- Toremifene citrate USP/EP/BP
- (Z)-2-(4-(4-chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)-N,N-dimethylethan-1-amine 2-hydroxypropane-1,2,3-tricarboxylate
- Toremifene Citrate (FC 1157a)
- fareston
- Toremifene citrat
- Oremifene Citrate
- Toremifene Citrate (NK 622)
- Ethanamine, 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
- (Z)-2-(4-(4-chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)-N,N-dimethylethan-1-amine
- (2-{4-[(1Z)-4-chloro-1,2-diphenylbut-1-en-1-yl]phenoxy}ethyl)dimethylamine
- 89778-27-8
- 89778-29-8
- C32H36CINO8
- XYREM
- Analgesics
- Active Pharmaceutical Ingredients
- Amines
- Aromatics
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
