ADU-S100 ammonium salt
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- CAS-Nr.
- 1638750-96-5
- Englisch Name:
- ADU-S100 ammonium salt
- Synonyma:
- MIW815 ammonium salt;ADU-S100 ammonium salt;ML RR-S2 CDA (ammonium salt);STING-INDUCER-1 AMMONIUM SALT;ML RR-S2 CDA ammonium salt(ADU-S100);ADU-S100 ammonium salt, 10 mM in DMSO;Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-, cyclic nucleotide, ammonium salt (1:2);inhibit,ADU S100 ammonium salt,TMEM173,STING,MIW815,Inhibitor,MIW-815,Stimulator of Interferon Genes,MITA,MPYS,ERIS,ADU-S100,ML RR-S2 CDA,MIW 815,ADUS100 ammonium salt
- CBNumber:
- CB33155065
- Summenformel:
- C20H27N11O10P2S2
- Molgewicht:
- 707.57
- MOL-Datei:
- 1638750-96-5.mol
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ADU-S100 ammonium salt Eigenschaften
- storage temp.
- Store at -20°C
- L?slichkeit
- DMSO: 15 mg/ml; Water: 12.5 mg/ml
- Aggregatzustand
- A solid
- Farbe
- White to off-white
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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ADU-S100 ammonium salt Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
ML RR-S2 CDA is a synthetic cyclic dinucleotide (CDN) that contains non-canonical 2''5''-phosphodiester bonds and is an activator of stimulator of interferon genes (STING). It contains mixed linkages (ML) with both 2''5'' and 3''5'' linkages, which leads to increased thermal stability of human STING in a differential scanning fluorimetry (DSF) assay. ML RR-S2 CDA increases type I interferon production by THP-1 human monocytes relative to unmodified cyclic di-AMP (CDA; ), indicating the ML enhances its action at human STING. It induces expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and Mcp-1 in murine bone marrow macrophages (BMM) isolated from wild-type, but not STING
-/-, mice. ML RR-S2 CDA also induces IFN-β expression in peripheral blood mononuclear cells (PBMCs) isolated from donors carrying STING
WT/WT, STING
WT/REF, and STING
WT/HAQ alleles.
In vivo, ML RR-S2 CDA initiates tumor regression and prevents tumor growth upon tumor cell reimplantation in 4T1 murine mammary and CT26 murine colon cancer models.
ADU-S100 ammonium salt Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
ADU-S100 ammonium salt Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 45)Lieferanten
1638750-96-5()Verwandte Suche:
- ML RR-S2 CDA (ammonium salt)
- Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-, cyclic nucleotide, ammonium salt (1:2)
- ML RR-S2 CDA ammonium salt(ADU-S100)
- MIW815 ammonium salt
- STING-INDUCER-1 AMMONIUM SALT
- ADU-S100 ammonium salt
- inhibit,ADU S100 ammonium salt,TMEM173,STING,MIW815,Inhibitor,MIW-815,Stimulator of Interferon Genes,MITA,MPYS,ERIS,ADU-S100,ML RR-S2 CDA,MIW 815,ADUS100 ammonium salt
- ADU-S100 ammonium salt, 10 mM in DMSO
- 1638750-96-5
