22(R)-hydroxy Cholesterol Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
The liver X receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols. LXRs regulate the oxysterol-
induced expression of cholesterol 7α-
hydroxylase, the rate limiting enzyme of classic bile acid synthesis. 22(R)-
hydroxy Cholesterol is an endogenous agonist for LXRs that activates LXRα with an EC
50 value of 325 nM. 22(R)-
hydroxy Cholesterol, acting through LXR heterodimerized with the retinoid X receptor, induces the expression of the ABCA1 reverse cholesterol transporter. This activity increases the efflux of cholesterol from enterocytes and thus inhibits the overall absorption of cholesterol. 22(R)-
hydroxy Cholesterol can be used as a substrate to monitor cholesterol transport or as an endogenous positive control for testing LXR agonists which have potential as therapeutic agents for the treatment of atherosclerosis.
Verwenden
Bovine aortic endothelial cells were treated with 22(R)-Hydroxycholesterol to study the effects on production of free radicals and in studies related to fatty acid metabolism.
Definition
ChEBI: An oxysterol that is the 22R-hydroxy derivative of cholesterol.
Allgemeine Beschreibung
22(
R)-hydroxycholesterol is a diastereomer of 22(
S)-hydroxycholesterol. It is present in neonate brain.
22(R)-hydroxy Cholesterol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
