4-(4-AMINOPHENYL)MORPHOLIN-3-ONE Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

4-(4-AMINOPHENYL)MORPHOLIN-3-ONE is Off-White Solid

Verwenden

4-(4-AMINOPHENYL)MORPHOLIN-3-ONE is used in the preparation of various Morpholine based pharmaceuticals.

Synthese

2-anilinoethanol (11) was condensed with ethyl chloroacetate in the presence of potassium tert-butoxide in tetrahydrofuran to afford the required phenylmorpholinone (12). Nitration of the intermediate morpholinone (12) in a solution of concentrated sulphuric acid with nitric acid below room temperature provided after recrystallization the para-product (13) in > 99.5% HPLC purity. The mother liquor was enriched predominantly with unwanted ortho - and meta-isomers together with depleted para-product. By subsequent hydrogenation of the nitro group in 13 with palladium on charcoal in methanol the 4-(4-Aminophenyl)morpholin-3-one (14) was obtained.

[1] W. MEDERSKI; Markus W; P Wendel. Practical and efficient processes for the preparation of 4-(4-aminophenyl)morpholin-3-ones on a larger scale: precursor of factor Xa inhibitors[J]. Heterocycles, 2007, 74 1: 437-445. DOI:10.3987/COM-07-S(W)22.

4-(4-AMINOPHENYL)MORPHOLIN-3-ONE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

4-(4-AMINOPHENYL)MORPHOLIN-3-ONE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Shanghai Rochi Pharmaceutical Co.,Ltd.	21-38751876 +8615000076078	info@rochipharma.com	China	505	58
Beijing Mediking Biopharm Co., Ltd	15901403431	sales01@mediking.cn	China	152	58
Hebei Chuanghai Biotechnology Co., Ltd	+86-15350571055	Sibel@chuanghaibio.com	China	8738	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971	deasea125996@gmail.com	China	2472	58
Anhui Ruihan Technology Co., Ltd	+undefined17756083858	daisy@anhuiruihan.com	China	973	58
Hebei Ganmiao New material Technology Co., LTD	+86-17332992504	sales8@hbganmiao.com	China	300	58
Handan City Zechi trading Co., LTD	+86-19003396151	13165586887@163.com	China	475	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Nanjing Gold Pharmaceutical Technology Co. Ltd.	025-84209270 15906146951		CHINA	115	55

438056-69-0()Verwandte Suche:

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• Rivaroxaban Intermediate 1
• 4-(4-aMinophenyl) Morpholinone
• 3-Morpholinone, 4-(4-aminophenyl)-
• 4-(4-Aminophenyl)morpholin-3-one ,97%
• 4-(3-Oxo-4-Morpholinyl)aniline
• 4-(3-Oxo-4-Morpholinyl)aniline-d4
• 4-(4-AMinophenyl)Morpholin-3-one(For Rivaroxaban)
• 4-(4-AMinophenyl)Morpholin-3-1
• 4-(4-AMinophlenyl)Morpholin-3-one
• Rivaroxaban Impurity 37
• 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE
• 4-(4-aminophenyl)morphin-3-one
• 4-(-4-amino phenyl0-3-Morpholine
• 4-(4-Aminophenyl)-2,2,5,5,6,6-d6-morphoIin-3-one
• Rivaroxaban intermdiate
• 4-(4-Aminophenyl)morpholin-3-one >
• in-3-one
• Rivaroxaban Aminophenyl Impurity
• 4-(4-Aminophenyl)-3-Morpholine
• 4-(3-Oxomorpholino)aniline
• 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE 438056-69-0
• 4-(4-AMINOPENYL)MORPHOLIN-3-ONE
• 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE ISO 9001：2015 REACH
• Rivaroxaban intermediates，4-(4-aminophenyl)morpholin-3-one
• 4-(4-Aminophenyl)morpholin-2-one
• 4-(4-Aminophenyl)morpholin-3-one (Rivaroxaban Intermediate)
• Rivaroxaban Impurity-1/4-(4-Aminophenyl)-3-morpholinone
• 2-Amino-11-picoline
• 4-(4-aminophenyl)mor
• 4-(4-AMINOPHENYL)MORPHOLIN-3-ON
• 4-(4-Aminophenyl)morphilin-3-one
• 4-(4-aminophenyl)- 3-morpholinon
• (4-Aminophenyl)Morpholin-3-one
• Aminophenylmorpholinone
• 4-(4-Aminophernyljmorpholin-3-one
• 4-(4-aminophenyl) morpholin-3-one Rivaroxaban Intermediate 1
• 4-(4-AMINO PHENYL)MORPHOLINE-3-ONE
• 4-(4-AMinophenyl)-3-Morpholinone
• 4-(4-aMinophenyl)Morpholine-3- ketone
• Rivaroxaban InterMediate
• 438056-69-0
• 43805-69-0
• Amines and Anilines
• Heterocycles
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• Aromatics
• Intermediates & Fine Chemicals
• Pharmaceuticals
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• Intermediate of Rivaroxaban