K-252B Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
K252b is an indolocarbazole isolated from the actinomycete
Nocardiopsis, first described as an inhibitor of protein kinase C. However, as this compound does not freely pass through the cell membrane, it is used to inhibit extracellular kinases (ectokinases) of cells in culture. K252b inhibits receptor-
mediated degranulation from basophil-
like RBL-
2H3 cells (IC
50 = 0.5 μg/ml) and human basophils. This extracellular inhibitor is also used in comparison studies with the closely related, cell-
permeable inhibitor K252a, particularly in studies of neuronal differentiation.
Chemische Eigenschaften
Yellow solid
Verwenden
K252A is a staurosporine analogue isolated from a Nocardiopsis strain as a potent inhibitor of protein kinase C. K252A exhibits potent antitumour activity but shows no antimicrobial activity in vitro, or in vivo toxicity in rodents. While K252A is a potent inhibitor of Ca2+/calmodulin kinase II, it is also active against other kinases, notably myosin light chain kinase, cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and cGMP-dependent protein kinase (PKG).
K-252B Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
