ANTI-CASK/LIN2 (KA-17) Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anti-CASK/LIN2 (KA-17) antibody produced in rabbit is suitable for:
- immunoprecipitation at a concentraqtion of 5-10μg, using lysate of 3x105 cultured MDCK cells
- western blot (chemiluminescent) at a dilution of 1:300, using whole cell extract of cultured human Jurkat and dog MDCK kidney cells
Allgemeine Beschreibung
Calcium/Calmodulin-dependent Serine Kinase (CASK/Lin-2) is predominant in the brain, may be ubiquitously expressed. It localizes to the lateral and/or basal plasma membrane regions in epithelial cells.
Biochem/physiol Actions
CASK/Lin-2 (Calcium/Calmodulin-dependent Serine Kinase) is translocated into the nucleus to regulate gene expression. It interacts via its PDZ domain with the cytosolic tail of the transmembrane cell surface heparin sulfate proteoglycan Syndecan-2. In neurons it interacts with neurexins. In addition, CASK/Lin-2 is capable of interacting with the actinbinding band 1 protein, neuronal munc18-1-interacting protein 1(Mint-1/Lin-10), protein lin-7 homolog A (Veli/Lin-7) proteins, junctional adhesion molecule (JAM), disks large homolog 1 (hDlg), and the nuclear T-box brain transcription factor 1 (Tbr-1).
ANTI-CASK/LIN2 (KA-17) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
