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Recombinant Human PTEN

Recombinant Human PTEN Struktur
CAS-Nr.
Englisch Name:
Recombinant Human PTEN
Synonyma:
Human PTEN;Mouse PTEN;PTEN human;MMAC1 elisa kit;Recombinant Human PTEN;Phosphatidylinositol-3;Phosphatase and tensin homolog;5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
CBNumber:
CB3484504
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

Recombinant Human PTEN Eigenschaften

storage temp. 
-70°C

Sicherheit

Recombinant Human PTEN Chemische Eigenschaften,Einsatz,Produktion Methoden

Enzyminhibitor

This tumor-suppressing, Mg2+-dependent dual-specificity protein phosphatase (MW = 47166 g/mol; GenBank: AAD13528.1), which catalyzes the dephosphorylation of phosphotyrosine-, phosphoserine- and phosphothreonine-containing proteins, is also a lipid phosphatase (Reaction: Phosphatidylinositol 3,4,5-trisphosphate + H2O Phosphatidylinositol 4,5-bisphosphate + Pi), with the following in vitro substrate preference: PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. PTEN antagonizes PI3K-AKT/PKB signaling by dephosphorylating phosphoinositides and reduces cell cycle progression and survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. PTEN catalyzes the dephosphorylation of tyrosine-phosphorylated focal adhesion kinase, inhibiting cell migration and integrin-mediated cell spreading. PTEN also modulates AKT-mTOR signaling. PTEN plays an essential role in the maintenance of genome stability. PTEN also dephosphorylates MCM2 and inhibits replication fork progression under replication stress, suggesting that PTEN is involved in an S-phase checkpoint. DNA molecular combing analysis revealed that replication forks in PTEN-proficient cells are subject to more efficient braking in response to fork stalling than the forks in PTEN-deficient cells.

Recombinant Human PTEN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Recombinant Human PTEN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 61)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai fantai biology science and technology co., ltd 15601885736
2114786541@qq.com China 206 58
Shanghai Huzhen Industrial Co., LTD 021-60345367 13916550749
sales@shzbio.com China 9965 58
ZSGB-BIO 02-400-810-9781 400810978
sales@zsbio.com China 2887 58
IQ Products 1-0031505757000 0031505757000
marketing@iqproducts.nl China 579 58
Wuhan Fine Biotech Co Ltd 13047170542
marketing@fn-test.com China 6600 58
Wanlei Life Sciences (Shenyang) Co Ltd 400-6020407
sales@wanleibio.com China 1216 58
Beijing Biosynthesis Biotechnology Co Ltd 400-9019800
sales@bioss.com.cn China 6273 58
Adooq Bioscience LLC 400-025-6535
sales@adooq.cn China 6215 58
Shanghai Zhenke Biotechnology Co., Ltd 17317792356
3022304776@qq.com China 7269 58
Shanghai Sig Biotechnology Co., Ltd 021-57810052 18930344717
2089316240@qq.com China 8000 58

  • MMAC1 elisa kit
  • Recombinant Human PTEN
  • 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  • PTEN human
  • Phosphatase and tensin homolog
  • Phosphatidylinositol-3
  • Mouse PTEN
  • Human PTEN
  • proteins
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