N-((4-Methoxyphenyl)methyl)-N',N'-dimethyl-N-2-pyridinyl-1,2-ethan-diamin, (Z)-2-butendioat (1:1) Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Beschreibung
Pyrilamine maleate (also known as Mepyramine) is a first generation antihistamine that acts as an inverse agonist at the histamine H
1 receptor. It is reported to bind with high affinity to a G
q/11 protein-coupled form of the receptor and to promote a G protein-coupled inactive state of the H
1 receptor that interferes with the G
q/11-mediated signaling of the endogenously expressed receptor, as well as to reduce G protein availability for other non-related receptors associated with this signaling pathway. Mepyramine has been shown to inhibit histamine-induced inositol phosphate production with a log EC
50 value of -7.94.
Chemische Eigenschaften
solid
Verwenden
Pyrilamine maleate Selective inverse agonist for the H-1 histamine receptor. Pyrilamine Maleate is commonly utilized as a radioligand ([3H]Mepyramine) binding assay for the H1 receptor. And also used to exhibit blocking ability of KCNQ/M channels which is potentially related to an adverse effect seen in excess intake of antihistamines.
Allgemeine Beschreibung
White crystals or powder. Melting point 100-101°C. Bitter saline taste. An antihistaminic medicine.
Air & Water Reaktionen
Water soluble.
Reaktivit?t anzeigen
PYRILAMINE MALEATE is an acidic salt of an amine. Usually does not react as either oxidizing agents or reducing agents but such behavior is not impossible. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Health Hazard
SYMPTOMS: Symptoms of exposure to PYRILAMINE MALEATE may include drowsiness, potentiation of the sedative effect of barbituates, fatigues, vertigo, incoordination, tremor, muscle weakness, dryness of the mouth and throat, tinnitus, pupillary dilation, blurred vision, urinary retention, impotence, epigastric and intestinal pain, anorexia, nausea, vomiting, diarrhea, excitation, euphoria, insomnia, nervousness, palpitation, tachycardia, hypotension, hypersensitivity reactions, respiratory depression, coma and delirium.
Brandgefahr
Flash point data for PYRILAMINE MALEATE are not available, however PYRILAMINE MALEATE is probably combustible.
Biologische Aktivit?t
Selective inverse agonist for the H 1 receptor. Inhibits histamine induced inositol phosphate (InsP) production (log EC50 = -7.94) and intracellular calcium mobilization. Sequesters G q/11 protein, reducing its availability for other receptors associated with the same signaling pathway.
Sicherheitsprofil
A human poison by
ingestion. An experimental poison by
ingestion, subcutaneous, intravenous, and
intraperitoneal routes. Experimental
reproductive effects. Questionable
carcinogen with experimental tumorigenic
data. Mutation data reported. An
antihistamine. When heated to
decomposition it emits toxic fumes of NOx.
N-((4-Methoxyphenyl)methyl)-N',N'-dimethyl-N-2-pyridinyl-1,2-ethan-diamin, (Z)-2-butendioat (1:1) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
