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JAK3 INHIBITOR VI

JAK3 INHIBITOR VI Struktur
856436-16-3
CAS-Nr.
856436-16-3
Englisch Name:
JAK3 INHIBITOR VI
Synonyma:
JI6;JAK3 INHIBITOR VI
CBNumber:
CB3787012
Summenformel:
C19H17N3O4S
Molgewicht:
383.42098
MOL-Datei:
856436-16-3.mol

JAK3 INHIBITOR VI Eigenschaften

storage temp. 
+2C to +8C
L?slichkeit
water: 1 mg/mL || DMSO: 5 mg/mL
Aggregatzustand
Yellow solid
Farbe
yellow
Wasserl?slichkeit
water: 1mg/mL
DMSO: 5mg/mL
InChI
1S/C18H13N3O.CH4O3S/c22-18-16(10-14-4-2-8-20-14)15-9-12(5-6-17(15)21-18)13-3-1-7-19-11-13;1-5(2,3)4/h1-11,20H,(H,21,22);1H3,(H,2,3,4)/b16-10-;
InChIKey
ZUDPNBZMAJGYTE-HYMQDMCPSA-N
SMILES
[S](=O)(=O)(O)C.[nH]1c(ccc1)\C=C2\c3c(ccc(c3)c4cnccc4)NC\2=O

Sicherheit

WGK Germany  WGK 1
Speicherklasse 11 - Combustible Solids

JAK3 INHIBITOR VI Chemische Eigenschaften,Einsatz,Produktion Methoden

Allgemeine Beschreibung

A cell-permeable, potent, and reversible inhibitor of Janus kinase 3 (JAK3) (IC50 = 27 nM). Reported to bind to the enzyme active site and prevent IL-2-induced phosphorylation of JAK3 and STAT5. Also reported to inhibit IL-2-induced cell proliferation (IC50 = 760 nM for murine CTLL cells and 250 nM for human T-cells). Shown to alleviate oxazolone-induced ear edema in mice with an efficacy comparable to Dexamethasone (Cat. No. 265005) and displays ~16-fold greater selectivity over JAK2.

Biochem/physiol Actions

Cell permeable: yes

JAK3 INHIBITOR VI Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


JAK3 INHIBITOR VI Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 21)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19936 58
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354
marketing@targetmol.com United States 32466 58
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD 13816107857
sales@fortunechem-sh.com China 981 58
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51395 80
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720
klq@cw-bio.com China 9692 55
Changzhou Chenhong Biotechnology Co., Ltd. +86-0519-85788828 +86-13775037613
sales@chemrenpharm.com China 4058 58
Beijing Biocreative Technology Co., Ltd. 15522676233
3007606172@qq.com China 1248 58
TargetMol Chemicals Inc. 4008200310 15002144251
marketing@tsbiochem.com China 24957 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627
customer_service@efebio.com China 11972 58
Sangon Biotech (Shanghai) Co.,Ltd. --
Sales@sangon.com China 6710 58

  • JAK3 INHIBITOR VI
  • JI6
  • 856436-16-3
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