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Meticillin

methicillin  Struktur
61-32-5
CAS-Nr.
61-32-5
Bezeichnung:
Meticillin
Englisch Name:
methicillin
Synonyma:
Metin;C07177;BRL-1241;Metacillin;Dimocillin;Methcilline;methicillin;Dimethoxyphenyl Penicillin;MRSA Selective Supplement;2,6-Dimethoxyphenylpenicillin
CBNumber:
CB3889080
Summenformel:
C17H20N2O6S
Molgewicht:
380.42
MOL-Datei:
61-32-5.mol

Meticillin Eigenschaften

Siedepunkt:
640.0±55.0 °C(Predicted)
Dichte
1.44±0.1 g/cm3(Predicted)
pka
pKa 2.77± 0.04(H2O,t = 25,c=0.0097) (Uncertain)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22
WGK Germany  3
RTECS-Nr. XH2379000
Giftige Stoffe Daten 61-32-5(Hazardous Substances Data)
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P330 Mund ausspülen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Meticillin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.

Verwenden

Antibacterial.

Definition

ChEBI: A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 2,6-dimethoxybenzoyl group.

Antimicrobial activity

2,6-Dimethoxyphenylpenicillin; methicillin (international non-proprietary name). The first β-lactamase-resistant semisynthetic penicillin. It was initially used widely but has been superseded by other group 3 members and is no longer commercially available.
It is less active than benzylpenicillin or other group 3 penicillins. It is very stable to staphylococcal β-lactamase and is active against β-lactamaseproducing strains of Staph. aureus that do not produce a functional PBP 2a. Resistance is common among staphylococci, with the incidence geographically diverse. Most methicillin-resistant staphylococcal isolates display multiresistance.
It is not acid resistant, and must therefore be administered parenterally. About 10% is metabolized, with 60–80% of the dose excreted in the urine. Toxicity is similar to that of other group 3 penicillins. Nephritis appears to be more common than with other penicillins.

Pharmakologie

Like other semisynthetic penicillins, methicillin exhibits an antibacterial effect similar to that of benzylpenicillin. The main difference between methicillin and benzylpenicillin is that it is not inactivated by the enzyme penicillinase, and therefore it is effective with respect to agents producing this enzyme (staphylococci). It is used for infections caused by benzylpenicillinresistant staphylococci (septicemia, pneumonia, empyemia, osteomyelitis, abscesses, infected wounds, and others). Synonyms of this drug are cinopenil, celbenin, staphcillin, and others.

Meticillin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Meticillin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 13)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354;
support@targetmol.com United States 39039 58
BOC Sciences 1-631-485-4226; 16314854226
info@bocsci.com United States 9920 65
Beijing HuaMeiHuLiBiological Chemical 010-56205725
waley188@sohu.com China 12335 58
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969
isunpharm@qq.com China 4769 55
Chizhou Kailong Import and Export Trade Co., Ltd.
xg01_gj@163.com China 9484 50
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51395 80
Alta Scientific Co., Ltd. 022-6537-8550 15522853686
sales@altasci.com.cn China 4511 55
Shanghai Han-Xiang Chemical Co., Ltd. 15971444841 17754423994
candy@biochempartner.com China 3061 58
TargetMol 400-821-0310 15002144251
xuexiang.shao@tsbiochem.com China 29103 58

61-32-5(Meticillin)Verwandte Suche:


  • methicillin
  • Methcilline
  • 2,6-Dimethoxyphenyl-penicillin, Methicillin Selective Supplement, Methicillin, Staphcillin
  • MRSA Selective Supplement
  • (2S,5R,6R)-6-(2,6-Dimethoxybenzoylamino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylic acid
  • 2,6-Dimethoxyphenylpenicillin
  • BRL-1241
  • Dimocillin
  • Metacillin
  • C07177
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 6-[(2,6-diMethoxybenzoyl)aMino]-3,3-diMethyl-7-oxo-, (2S,5R,6R)-
  • Dimethoxyphenyl Penicillin
  • Metin
  • 61-32-5
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