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tert-Butyl[2-hydroxy-3-[2-[(tetrahydro-2-furyl)methoxy]phenoxy]propyl]ammoniumchlorid

tert-butyl[2-hydroxy-3-[2-[(tetrahydro-2-furyl)methoxy]phenoxy]propyl]ammonium chloride Struktur
35108-88-4
CAS-Nr.
35108-88-4
Bezeichnung:
tert-Butyl[2-hydroxy-3-[2-[(tetrahydro-2-furyl)methoxy]phenoxy]propyl]ammoniumchlorid
Englisch Name:
tert-butyl[2-hydroxy-3-[2-[(tetrahydro-2-furyl)methoxy]phenoxy]propyl]ammonium chloride
Synonyma:
Y 6124;Adobiol;Bufetolol-hydrochloride;bufetolol hydrochloride;1-tert-Butylamino-3-[o-(tetrahydrofurfuryloxy)phenoxy]-2-propanol hydrochloride;DL-1-tert-Butylamino-3-[o-(tetrahydrofurfuryloxy)phenoxy]-2-propanol hydrochloride;tert-butyl[2-hydroxy-3-[2-[(tetrahydro-2-furyl)methoxy]phenoxy]propyl]ammonium chloride;2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[2-[(tetrahydro-2-furanyl)methoxy]phenoxy]-, hydrochloride
CBNumber:
CB3901559
Summenformel:
C18H30ClNO4
Molgewicht:
359.8881
MOL-Datei:
35108-88-4.mol

tert-Butyl[2-hydroxy-3-[2-[(tetrahydro-2-furyl)methoxy]phenoxy]propyl]ammoniumchlorid Eigenschaften

Schmelzpunkt:
153.5-157°; mp 151-154°; (Diastereoisomer, mp 118°)

Sicherheit

Toxizit?t LD50 oral in rat: 1088mg/kg

tert-Butyl[2-hydroxy-3-[2-[(tetrahydro-2-furyl)methoxy]phenoxy]propyl]ammoniumchlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator

Bufetolol,ZYF Pharm

Manufacturing Process

To a solution of 1 gramm equivalent (g-eq.) of 1-bromo-3-[2- (tetrahydrofuran-2-yloxy)phenoxy]propan-2-ol in 30 ml of ethanol is added 1 g-eq. of t-butylamine, the mixture is refluxed for 6 hours, and then the ethanol is distilled off. The residue is dissolved in benzene and the solution is extracted twice with 5% oxalic acid. The aqueous extract is made alkaline with potassium hydroxide and the isolated oil is extracted with benzene. The benzene extract is dried over potassium carbonate and the benzene is distilled off to give of oily 1-(t-butylamino)-3-(o-((tetrahydrofurfuryl)oxy)phenoxy)-2- propanol. The corresponding acid fumarate melts at 128°-132°C.

Therapeutic Function

Antiarrhythmic, Beta-adrenergic blocker

tert-Butyl[2-hydroxy-3-[2-[(tetrahydro-2-furyl)methoxy]phenoxy]propyl]ammoniumchlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


tert-Butyl[2-hydroxy-3-[2-[(tetrahydro-2-furyl)methoxy]phenoxy]propyl]ammoniumchlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 1)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Nanjing Ningjitong Pharmaceutical Biotechnology Co., Ltd 0-19710401727 19710401727
3805829626@QQ.COM China 1405 58

35108-88-4(tert-Butyl[2-hydroxy-3-[2-[(tetrahydro-2-furyl)methoxy]phenoxy]propyl]ammoniumchlorid)Verwandte Suche:


  • tert-butyl[2-hydroxy-3-[2-[(tetrahydro-2-furyl)methoxy]phenoxy]propyl]ammonium chloride
  • 1-tert-Butylamino-3-[o-(tetrahydrofurfuryloxy)phenoxy]-2-propanol hydrochloride
  • 2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[2-[(tetrahydro-2-furanyl)methoxy]phenoxy]-, hydrochloride
  • Adobiol
  • bufetolol hydrochloride
  • Bufetolol-hydrochloride
  • DL-1-tert-Butylamino-3-[o-(tetrahydrofurfuryloxy)phenoxy]-2-propanol hydrochloride
  • Y 6124
  • 35108-88-4
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