O-(2,4-Dinitrophenyl)hydroxylamin
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- CAS-Nr.
- 17508-17-7
- Bezeichnung:
- O-(2,4-Dinitrophenyl)hydroxylamin
- Englisch Name:
- O-(2,4-dinitrophenyl)hydroxylamine
- Synonyma:
- 2,4-Dinitrophenylhydroxylamine;2,4-DinitrophenoxyaMine;NSC 148499;2,4-NitrophenoxyaMine;4-dinitrophenyl)hydroxylamine;1-aMinooxy-2,4-dinitro-benzene;O-(2,4-dinitrophenyl)hydroxylamine;HydroxylaMine,O-(2,4-dinitrophenyl)-;O-(2,4-Dinitrophenyl)hydroxylamine,98%;TIANFUCHEM--17508-17-7---O-(2,4-dinitrophenyl)hydroxylamine
- CBNumber:
- CB3922714
- Summenformel:
- C6H5N3O5
- Molgewicht:
- 199.12
- MOL-Datei:
- 17508-17-7.mol
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O-(2,4-Dinitrophenyl)hydroxylamin Eigenschaften
- Schmelzpunkt:
- 112.5°C
- Siedepunkt:
- 336.62°C (rough estimate)
- Dichte
- 1.6937 (rough estimate)
- Brechungsindex
- 1.6910 (estimate)
- storage temp.
- 2-8°C(protect from light)
- L?slichkeit
- DMSO (Sparingly), Methanol (Slightly)
- Aggregatzustand
- solid
- pka
- -1.07±0.70(Predicted)
- Farbe
- yellow
- InChI
- InChI=1S/C6H5N3O5/c7-14-6-2-1-4(8(10)11)3-5(6)9(12)13/h1-3H,7H2
- InChIKey
- YLACRFYIUQZNIV-UHFFFAOYSA-N
- SMILES
- NOC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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O-(2,4-Dinitrophenyl)hydroxylamin Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Light yellow solid
Verwenden
O-(2,4-Dinitrophenyl)hydroxylamine is a rapid active-site-directed inhibitor of D-amino acid oxidase; modification results in specific incorporation of an amine group into an accessible nucleophilic r
esidue with concomitant release of 2,4-dinitrophenol.
synthetische
To a stirred solution of 13.3 gm (0.1 mole) of t-butyl JV-hydroxycar-bamate and 5.6 gm (0.1 mole) of potassium hydroxide in 200 ml of absolute ethanol is added 20.2 gm (0.1 mole) of 2,4-dinitrochlorobenzene. The resultant deep red solution is stirred at room temperature for 1 hr; then enough glacial acetic acid is added dropwise to produce a light yellow solution. The solution is poured into 1.5 liters of cold water. The yellow oil which separates is gradually converted to crystals. The solid -butyl JV-(2,4-dinitrophenoxy)carbamate is separated, dried, and recrystallized from an ethyl acetate-hexane mixture to afford 16.4 gm (53%), m.p. 74-75°C. To 15 ml of trifluoroacetic acid is added 4 gm (0.0133 mole) of the i-butyl J/V-(2,4-dinitrophenoxy)carbamate. After the evolution of carbon dioxide has subsided, the solution is poured into 100 ml of ice water. The resultant oily layer crystallizes on standing to afford 2.5 gm (95%), m.p. 112°C (from ethanol).
Recently it was discovered that the alkylation of ethyl JV-hydroxy-carbamate under alkaline conditions, particularly in a DMF medium at 60°C in the presence of sodium bicarbonate, leads to the ultimate formation of O-alkylated hydroxylamines. On the other hand, at 80-85°C, the direct alkylation without the presence of a base ultimately leads to N-alkylhydrox-ylamines (see Table I) [59]. The reaction of ethylazidoformate with an alcohol, while perhaps hazardous, may have some merit (Eqs. 31-33). The overall yield, based on ethyl chloroformate, is said to be on the order of 60%.
O-(2,4-Dinitrophenyl)hydroxylamin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
O-(2,4-Dinitrophenyl)hydroxylamin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 233)Lieferanten
17508-17-7(O-(2,4-Dinitrophenyl)hydroxylamin)Verwandte Suche:
- HydroxylaMine,O-(2,4-dinitrophenyl)-
- 1-aMinooxy-2,4-dinitro-benzene
- 2,4-NitrophenoxyaMine
- NSC 148499
- O-(2,4-dinitrophenyl)hydroxylamine
- 4-dinitrophenyl)hydroxylamine
- TIANFUCHEM--17508-17-7---O-(2,4-dinitrophenyl)hydroxylamine
- O-(2,4-Dinitrophenyl)hydroxylamine,98%
- 2,4-DinitrophenoxyaMine
- 2,4-Dinitrophenylhydroxylamine
- 17508-17-7
- nitro-compound
- Amines
- Aromatics
- Inhibitors
