Levothyroxinnatrium Chemische Eigenschaften,Einsatz,Produktion Methoden
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Chemische Eigenschaften
Levothyroxine sodium is White Solid
History
On August 14, 1997, the FDA declared levothyroxine sodium tablets a “new drug.” On February 15, 2017, the FDA approved levothyroxine sodium (brand name: Tirosint-SOL, developed by IBSA Pharma Inc.) oral solution for hypothyroidism and pituitary thyroid-stimulating hormone (TSH) suppression. Subsequently, the FDA approved two changes to the labeling of levothyroxine sodium (Tirosint-SOL, IBSA). The first change was for use in combination with a proton pump inhibitor (PPI). The second adjustment was the timing of levothyroxine sodium administration. The approved labeling changes were based on the results of two clinical studies that found no interaction between levothyroxine sodium and PPIs, and the same results were shown when administered 15 minutes and 30 minutes before breakfast. This led to the approval to label levothyroxine sodium as the only FDA-approved LT4 therapy that does not have label interactions with PPIs and can be taken 15 minutes before breakfast.
Verwenden
One of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.
Indications
Levothyroxine sodium (Levothroid, Synthroid, Levoxine)
is the sodium salt of the naturally occurring levorotatory
isomer of T
4. It is the preparation of choice for
maintenance of plasma T
4 and T
3 concentrations for
thyroid hormone replacement therapy in hypothyroid
patients. It is absorbed intact from the gastrointestinal
tract, and its long half-life allows for convenient oncedaily
administration. Since much of the T
4 is deiodinated
to T
3, it is usually unnecessary to use more expensive
preparations containing both T
4 and T
3.The aim
is to establish euthyroidism with measured serum concentrations
of T
4, T
3, and TSH within the normal range.
The TSH-suppressive effects of exogenous T
4 also
prove useful in removing the stimulatory effects of TSH
on the thyroid gland in the management of simple
nonendemic goiter, chronic thyroiditis, and TSHdependent
thyroid carcinoma.
Definition
ChEBI: The sodium salt of L-thyoxine. It is used as replacement therapy in the treatment of hypothyroidism.
Allgemeine Beschreibung
Levothyroxine sodium,O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-2-tyrosinemonosodium salt, hydrate (Synthroid, Letter, Levoxine,Levoid), is the sodium salt of the levo isomer of thyroxine,which is an active physiological principle obtained from thethyroid gland of domesticated animals used for food by humans.It is also prepared synthetically. The salt is a light yellow,tasteless, odorless powder. It is hygroscopic but stablein dry air at room temperature. It is soluble in alkali hydroxides,1:275 in alcohol, and 1:500 in water, to give a pH ofabout 8.9.
Clinical Use
Liothyronine sodium occurs in vivo together withlevothyroxine sodium; it has the same qualitative activitiesas thyroxine but is more active. It is absorbed readily fromthe gastrointestinal tract, is cleared rapidly from the bloodstream,and is bound more loosely to plasma proteins than isthyroxine, probably because of the less acidic phenolic hydroxylgroup.Its uses are the same as those of levothyroxine sodium,including treatment of metabolic insufficiency, male infertility,and certain gynecological disorders.
Levothyroxinnatrium Upstream-Materialien And Downstream Produkte
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