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Gepefrine

Gepefrine Struktur
18840-47-6
CAS-Nr.
18840-47-6
Englisch Name:
Gepefrine
Synonyma:
Gepefrine;Unii-V51rrx51vh;Gepefrine [inn];Rivastigmine Impurity 25;(S)-3-(2-AMINOPROPYL)PHENOL;Phenol, 3-[(2S)-2-aminopropyl]-;Metaramine bitartrate Impurity 63;Metaraminol Bitartrate Impurity 90;Metaraminol Bitartrate Impurity 63
CBNumber:
CB41116643
Summenformel:
C9H13NO
Molgewicht:
151.21
MOL-Datei:
18840-47-6.mol

Gepefrine Eigenschaften

Schmelzpunkt:
155-158°
alpha 
D25 +31.8° (c = 2 in methanol)
Siedepunkt:
281.0±15.0 °C(Predicted)
Dichte
1.070±0.06 g/cm3(Predicted)
pka
9.86±0.10(Predicted)
InChI
InChI=1S/C9H13NO/c1-7(10)5-8-3-2-4-9(11)6-8/h2-4,6-7,11H,5,10H2,1H3/t7-/m0/s1
InChIKey
WTDGMHYYGNJEKQ-ZETCQYMHSA-N
SMILES
C1(O)=CC=CC(C[C@@H](N)C)=C1

Sicherheit

Gepefrine Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator

Pressionorm,Helopharm,W. Germany,1981

Manufacturing Process

Hydrolysis of D-(+)-1-(3-rnethoxyphenyl)-2-aminopropane: 2.42 mols (40 g) of the compound are dissolved in 6N hydrochloric acid in a bomb tube consisting of stainless steel and having a capacity of 500 ml. Hydrogen chloride gas is passed into the ice-cooled solution until this is saturated, The solution is then heated to 130°C for 2 hours in an air bath. After cooling and driving off the hydrochloric acid at a slightly elevated temperature, the hydrochloride of the 3-hydroxyphenyl derivative is present in the form of a yellowish syrup.
The free base can be liberated from the hydrochloride by extracting a butanol solution of the hydrochloride several times with sodium bicarbonate solution. After recrystallization from isopropanol/ligroin, the yield of D-(+)-1-(3- hydroxyphenyl)-2-aminopropane amounts to 33.0 g, corresponding to 90.1% of theory relative to the D-form. Melting point = 152°C to 154°C.

Therapeutic Function

Antihypotensive

Gepefrine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Gepefrine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 21)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Moxin Chemicals
+86-17320513646 +8617320513646
anna@molcoo.com China 10000 58
ShenZhen H&D Pharmaceutical Technology Co., LTD
+8618627948422
sale@hdimpurity.com China 3681 58
JW & Y Pharmlab Co., Ltd. 021-64340559 13651849907;
xinyu_shi@jwypharmlab.com.cn China 11999 58
Bejing Famous Pharmaceutical Technology Co., Ltd. 13331045123
2559355526@qq.com China 14187 58
Shanghai zhigan biotechnology co., LTD
zhiqianbio@126.com China 19778 58
Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd 0371-88900765 18037465274
3430974218@qq.com China 14125 58
Shandong WorldSun Biological Technology Co., Ltd. 0531-88723173 18596073690
1047208234@qq.com China 7686 58
Hubei Xinyang Medical Technology Co., Ltd 15347293736
2853117764@yongstandards.com China 9999 58
Molcoo Chemicals Inc. 18627923403
3001039764@qq.com China 8248 58
Cato Research Chemicals Inc. 020-81960175-877 18933936954
tianwen.zhan@cato-chem.com China 7328 58

18840-47-6()Verwandte Suche:


  • Gepefrine [inn]
  • Unii-V51rrx51vh
  • (S)-3-(2-AMINOPROPYL)PHENOL
  • Gepefrine
  • Phenol, 3-[(2S)-2-aminopropyl]-
  • Metaraminol Bitartrate Impurity 63
  • Rivastigmine Impurity 25
  • Metaramine bitartrate Impurity 63
  • Metaraminol Bitartrate Impurity 90
  • 18840-47-6
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