ANTI-CYTOCHROME C Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anti-Cytochrome c antibody produced in sheep has been used in:
- immunocytochemistry
- immunostaining
- immunoblotting
- immunohistochemistry
Allgemeine Beschreibung
Anti-Cytochrome c produced in sheep using purified rabbit cytochrome c conjugated to keyhole limpet hemocyanin (KLH).
Biochem/physiol Actions
Cytochrome c controls cellular electron transport and energy metabolism. It is involved in the transfer of electrons between complex III and complex IV in the mitochondrial electron transport chain. It is involved in apoptosis and activates the death protease caspase-3 (CCP32). The presence of Bcl-2 on the organelles inhibits the release of cytochrome c from mitochondria during apoptosis. Along with Apaf-1, and procaspase-9, it forms an essential component of vertebrate ”apoptosome”. Activation of caspase-9 and other capsases directs apoptosis. Serum cytochrome c is a sensitive apoptotic marker in vivo, and increased serum cytochrome c level can serve as a negative prognostic marker.
ANTI-CYTOCHROME C Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
