Zoliprofen Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator

Zoliprofen,ZYF Pharm Chemical

Manufacturing Process

A mixture of 2-chlorothiazole (5.0 g), ethyl 2-(4-hydroxyphenyl)propionate (8.1 g), potassium carbonate powder (8.65 g) and dimethylformamide (80 ml) is stirred at 150°-155°C for 2.5 hours. The solvent is distilled out under reduced pressure. To the residue is added water and extracted with ether. The extract is washed with a 10% aqueous solution of sodium hydroxide and water and dried. The ether is evaporated. The residue is subjected to chromatography using silica gel and eluted with 50% benzene-hexane, benzene and 10% ether-benzene to yield ethyl 2-[4-(2-thiazolyloxy)- phenyl]propionate (5.8 g).
The product is dissolved in a mixture of a 20% aqueous solution of potassium hydroxide (30 ml) and 95% ethanol (30 ml). The solution is kept at room temperature for 30 minutes. The solvent is evaporated. The residue is acidified with hydrochloric acid after addition of water, and extracted with ether. The extract is washed with water and dried over magnesium sulfate. The solvent is distilled out. The residue is recrystallized from ether-hexane to give 2-[4-(2-thiazolyloxy)phenyl]propionic acid (4.8 g).
The product (5.0 g) is dissolved in an aqueous solution (30 ml) of sodium hydroxide (0.82 g). To the solution washed with ether is added an aqueous solution (5 ml) of calcium chloride 2 hydrate (1.6 g) to form a precipitate. The precipitate washed with water gives calcium 2-[4-(2-thiazolyloxy)phenyl]propionate (5.5 g) melting at 143°-145°C.

Therapeutic Function

Antiinflammatory, Analgesic

Zoliprofen Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Zoliprofen Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11972	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9835	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29867	58
Sangon Biotech (Shanghai) Co.,Ltd.	--	Sales@sangon.com	China	6710	58
Shanghai Amole Biotechnology Co., Ltd.	18017925202 18916960931	2596183085@qq.com	China	17238	58

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• Zoliprofen
• 480156-S
• Benzeneacetic acid, α-methyl-4-(2-thiazolyloxy)-
• Zoliprofen, 10 mM in DMSO
• 56355-17-0