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mersacidin

mersacidin Struktur
128104-18-7
CAS-Nr.
128104-18-7
Englisch Name:
mersacidin
Synonyma:
mersacidin;L-Isoleucinamide, L-cysteinyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-phenylalanyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-leucyl-L-prolylglycylglycylglycylglycyl-L-valyl-L-cysteinyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-leucyl-(2S,3S)-2-amino-3-mercaptobutanoyl-2,3-didehydroalanyl-L-α-glutamyl-L-cysteinyl...
CBNumber:
CB41317532
Summenformel:
C80H120N20O21S4
Molgewicht:
1826.19
MOL-Datei:
128104-18-7.mol

mersacidin Eigenschaften

Siedepunkt:
2116.4±65.0 °C(Predicted)
Dichte
1.39±0.1 g/cm3(Predicted)
pka
4.48±0.10(Predicted)

Sicherheit

mersacidin Chemische Eigenschaften,Einsatz,Produktion Methoden

Definition

ChEBI: A type-B lantibiotic containing 3-methyllanthionine and S-(2-aminovinyl)-3-methylcysteine residues and four intra-chain thioether bridges. It is obtained from Bacillus sp. HIL Y-85,54728 and is active in vivo ag inst methicillin-resistant Staphylococcus aureus (MRSA).

Synthese

Mersacidin is a polycyclic lantibiotic characterized by thioether-bridged rings formed by unusual amino acids like lanthionine. While naturally produced via ribosomal synthesis and post-translational modification, Solid-Phase Peptide Synthesis (SPPS) is the primary chemical route for preparing analogues. The main challenge in SPPS is the selective formation of these bridges, often addressed by either incorporating pre-formed lanthionine building blocks or inducing intramolecular Michael addition on the linear peptide. This chemical approach allows for systematic modification to create novel analogues with enhanced biological activity.

mersacidin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


mersacidin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 1)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Creative Peptides
info@creative-peptides.com United States 6083 56

128104-18-7()Verwandte Suche:


  • mersacidin
  • L-Isoleucinamide, L-cysteinyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-phenylalanyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-leucyl-L-prolylglycylglycylglycylglycyl-L-valyl-L-cysteinyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-leucyl-(2S,3S)-2-amino-3-mercaptobutanoyl-2,3-didehydroalanyl-L-α-glutamyl-L-cysteinyl...
  • 128104-18-7
  • C80H120N20O21S4
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