zerumbone
|
|
|
- CAS-Nr.
- 471-05-6
- Englisch Name:
- zerumbone
- Synonyma:
- zerumbone;Zerumbone-RM;ZeruMbone (6CI,7CI);zerumbone (Standard);Zingiber zerumbe extract;GIHNTRQPEMKFKO-SKTNYSRSSA-N;Zerumbone, NF-kappaB inhibitor;(2E,6E,10E)-2,6,9,9-Tetramethylcycloundeca-2,6,10-trienone;(2E,6E,10E)-2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one;(2E,6E,10E)-2,6,9,9-Tetramethyl-2,6,10-cycloundecatrien-1-one
- CBNumber:
- CB41346756
- Summenformel:
- C15H22O
- Molgewicht:
- 218.33
- MOL-Datei:
- 471-05-6.mol
|
zerumbone Eigenschaften
- Schmelzpunkt:
- 67-69℃
- Siedepunkt:
- 321.6±42.0 °C(Predicted)
- Dichte
- 0.887±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: ≥10mg/mL
- Aggregatzustand
- powder
- Farbe
- white to off-white
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
- Kosmetik-Inhaltsstoffe Funktionen
- SKIN CONDITIONING
- InChI
- InChI=1S/C15H22O/c1-12-6-5-7-13(2)14(16)9-11-15(3,4)10-8-12/h7-9,11H,5-6,10H2,1-4H3/b11-9+,12-8+,13-7+
- InChIKey
- GIHNTRQPEMKFKO-SKTNYSRSSA-N
- SMILES
- C1(=O)C=CC(C)(C)CC=C(C)CCC=C1C |c:8,t:2,13|
- LogP
- 4.168 (est)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi,N |
|
|
| R-S?tze: |
43-50 |
|
|
| S-S?tze: |
36/37-60-61 |
|
|
| RIDADR |
UN 3077 9 / PGIII |
|
|
| WGK Germany |
3 |
|
|
| Speicherklasse |
11 - Combustible Solids |
|
|
| Hazard Classifications |
Aquatic Acute 1
Skin Sens. 1 |
|
|
| Bildanzeige (GHS) |
 
|
| Alarmwort |
Warnung
|
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
|
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H400 |
Sehr giftig für Wasserorganismen. |
Kurzfristig (akut) gew?ssergef?hrdend |
Kategorie 1 |
Warnung |
|
P273, P391, P501 |
|
| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
|
zerumbone Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Zerumbone has been used:
- for liquid chromatography with mass spectrometry (LC-MS-MS)
- to investigate its potential application in the prevention
- treatment of esophageal squamous cell carcinomas (ESCC)
Definition
ChEBI: A sesquiterpenoid and cyclic ketone that is (1E,4E,8E)-alpha-humulene which is substituted by an oxo group at the carbon atom attached to two double bonds. It is obtained by steam distillati
n from a type of edible ginger, Zingiber zerumbet Smith, grown particularly in southeast Asia.
Allgemeine Beschreibung
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Anticancer Research
Zerumbone is isolated from the rhizomes of the wild ginger Zingiber zerumbet. It isfound to suppress the proliferation of breast cancer and colon cancer cells and alsoto prevent initiation and promotion of skin cancer in mice. It also suppresses theNF-κB activation and its sequential suppression of IκBα kinase activity, IκBαphosphorylation, IκBα degradation, p65 phosphorylation, nuclear translocation,and acylation. It downregulates the NF-κB-regulated gene products like FLIP, cyclinD1, TRAF1, COX2, Bfl-1/A1, MMP-9, Bcl-xL, ICAM-1, Bcl-2, c-myc, XIAP,survivin, IAP1, and IAP2, and thus, it potentiates apoptosis (Murakami et al. 2002;Sakinah et al. 2007).
zerumbone Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
zerumbone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 151)Lieferanten
471-05-6()Verwandte Suche:
- zerumbone
- (2E,6E,10E)-2,6,9,9-Tetramethyl-2,6,10-cycloundecatrien-1-one
- ZeruMbone (6CI,7CI)
- (2E,6E,10E)-2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one
- GIHNTRQPEMKFKO-SKTNYSRSSA-N
- 2,6,10-Cycloundecatrien-1-one, 2,6,9,9-tetramethyl-, (2E,6E,10E)-
- Zingiber zerumbe extract
- (2E,6E,10E)-2,6,9,9-Tetramethylcycloundeca-2,6,10-trienone
- Zerumbone-RM
- Zerumbone, NF-kappaB inhibitor
- zerumbone (Standard)
- 471-05-6
