kobusine Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Obtained by Suginome and Shimanouti from the precipitation liquors of crude
jesaconitine from Aconitum sachalinense, Fr. Schmidt, this alkaloid crystallizes
from Me2CO in the rhombic-bisphenoidal system and has (a:b:c = 1.0736: I:
0.9811). It furnishes crystalline salts: the hydrobromide crystallizes as the mono_x0002_hydrate, m.p. 288°C (dec.); [α]
22D + 40.68° (H20); hydrochloride (1.5 H20) has
m.p. 300°C (dec.);[α]
21Dl + 41.4° (H20); perchlorate, m.p. 185-7°C (dec.)
although a value of 220°C has also been recorded for this salt; platinichloride,
m.p. 262°C (dec.); picrate, m.p. 282-4°C (dec.) and methiodide, m.p. 287°C
(dec.). The alkaloid forms a diacetyl derivative, m.p. 139-140°C and catalytic
reduction followed by acetylation yields a triacetyltetrahydrokobusine, m.p.
183-4°C (dec.). The alkaloid cannot be hydrolyzed and is non-toxic.
Einzelnachweise
Suginome, Shimanouti., Annalen, 545, 220 (1940)
Okamoto., Chern. Pharm. Bull. (Tokyo), 7,44 (1959)
Natsume., ibid, 7,539 (1959)
kobusine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
