680C91
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- CAS-Nr.
- 163239-22-3
- Englisch Name:
- 680C91
- Synonyma:
- 680C91;680C91 >=98% (HPLC);680C91, 10 mM in DMSO;680C91, tryptophan 2,3-dioxygenase inhibitor;6-Fluoro-3-[(E)-2-(3-pyridinyl)vinyl]-1H-indole;(E)-6-fluoro-3-(2-(pyridin-3-yl)vinyl)-1H-indole;6-fluoro-3-[(E)-2-(pyridin-3-yl)ethenyl]-1H-indole;6-Fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl)-1H-indole;1H-Indole, 6-fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-;inhibit,Inhibitor,680C91,tryptophan 2,3-dioxygenasetryptophan catabolismAlzheimer’s Disease,680C-91
- CBNumber:
- CB41395451
- Summenformel:
- C15H11FN2
- Molgewicht:
- 238.26
- MOL-Datei:
- 163239-22-3.mol
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680C91 Eigenschaften
- Siedepunkt:
- 431.2±35.0 °C(Predicted)
- Dichte
- 1.305±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: ≥10mg/mL
- pka
- 15.92±0.30(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
- InChI
- 1S/C15H11FN2/c16-13-5-6-14-12(10-18-15(14)8-13)4-3-11-2-1-7-17-9-11/h1-10,18H/b4-3+
- InChIKey
- YBSDQTBCNYWBMX-ONEGZZNKSA-N
- SMILES
- Fc1ccc2c(\C=C\c3cccnc3)c[nH]c2c1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
41 |
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| S-S?tze: |
26-39 |
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| WGK Germany |
3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Eye Dam. 1 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H318 |
Verursacht schwere Augensch?den. |
Schwere Augensch?digung |
Kategorie 1 |
Achtung |
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P280, P305+P351+P338, P310 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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680C91 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
680C91 has been used:
- as a tryptophan 2,3 dioxygenase (TDO) inhibitor to study its effects on the pigmentation in Doryteuthis pealeii embryos
- as a TDO inhibitor to study its effects on esophageal squamous cell carcinoma in xenograft tumor assay
- as a tryptophan 2,3 dioxygenase 2 (TDO2) inhibitor to study its effects on toxic fragment formation in human embryonic kidney cells
Definition
ChEBI: A fluoroindole that is 6-fluoroindole in which the hydrogen at position 3 has been replaced by a 2-(pyridin-3-yl)vinyl group (trans configuration). It is a selective inhibitor of tryptophan 2,3-dioxygenase (TDO), which directs the conversi
n of trypophan to kynurenin.
Biochem/physiol Actions
680C91 is a potent inhibitor of the enzyme tryptophan 2,3-dioxygenase (TDO), which directs the conversion of trypophan to kynurenin. Kynurenin has recently been identified as an endogenous lignd of the arylhydrocarbon receptor (AHR). TDO is highly expressed in glioma cells, and contributes to AHR-mediated glioma cell survival and suppression of anti-tumor immune responses.
680C91 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
680C91 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 76)Lieferanten
- 680C91
- 1H-Indole, 6-fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-
- 6-Fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl)-1H-indole
- 680C91 >=98% (HPLC)
- 6-fluoro-3-[(E)-2-(pyridin-3-yl)ethenyl]-1H-indole
- inhibit,Inhibitor,680C91,tryptophan 2,3-dioxygenasetryptophan catabolismAlzheimer’s Disease,680C-91
- (E)-6-fluoro-3-(2-(pyridin-3-yl)vinyl)-1H-indole
- 680C91, tryptophan 2,3-dioxygenase inhibitor
- 680C91, 10 mM in DMSO
- 6-Fluoro-3-[(E)-2-(3-pyridinyl)vinyl]-1H-indole
- 163239-22-3
